Protein Domain : IPR004046

Type:  Domain Name:  Glutathione S-transferase, C-terminal
Description:  In eukaryotes, glutathione S-transferases (GSTs) participate in the detoxification of reactive electrophillic compounds by catalysing theirconjugation to glutathione. The GST domain is also found in S-crystallins from squid, and proteins with no known GST activity, such as eukaryotic elongation factors 1-gamma and the HSP26 family of stress-related proteins, which include auxin-regulated proteins in plants and stringent starvation proteins in Escherichia coli. The major lens polypeptide of cephalopods is also a GST [, , , ].Bacterial GSTs of known function often have a specific, growth-supporting role in biodegradative metabolism: epoxide ring opening and tetrachlorohydroquinone reductive dehalogenation are two examples of the reactions catalysed by these bacterial GSTs. Some regulatory proteins, like the stringent starvation proteins, also belong to the GST family [, ]. GST seems to be absent from Archaea in which gamma-glutamylcysteine substitute to glutathione as major thiol.Glutathione S-transferases form homodimers, but in eukaryotes can also form heterodimers of the A1 and A2 or YC1 and YC2 subunits. The homodimeric enzymes display a conserved structural fold. Each monomer is composed of a distinct N-terminal sub-domain,which adopts the thioredoxin fold, and a C-terminal all-helical sub-domain. This entry is the C-terminal domain. Short Name:  GST_C
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PF00043
PF14497

8 Found Ins

DB identifier Type Name
IPR005955 Family Maleylacetoacetate isomerase
IPR016639 Family Glutathione S-transferase (GST)
IPR005442 Family Glutathione S-transferase, omega-class
IPR003082 Family Glutathione S-transferase, Pi class
IPR003080 Family Glutathione S-transferase, alpha class
IPR003081 Family Glutathione S-transferase, Mu class
IPR003083 Family S-crystallin
IPR017298 Family Transcriptional regulator Ure2

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR010987 Domain Glutathione S-transferase, C-terminal-like

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
98733 D8RPJ6 PAC:15415947 Selaginella moellendorffii 418  
103322 D8RW70 PAC:15408146 Selaginella moellendorffii 272  
271267 D8S375 PAC:15421631 Selaginella moellendorffii 215  
271266 D8S373 PAC:15421628 Selaginella moellendorffii 215  
417676 D8S378 PAC:15405335 Selaginella moellendorffii 215  
142654 D8R0M0 PAC:15414237 Selaginella moellendorffii 215  
115750 D8SFL3 PAC:15402074 Selaginella moellendorffii 191  
121308 D8SNX9 PAC:15416746 Selaginella moellendorffii 731  
402877 D8QNB8 PAC:15407346 Selaginella moellendorffii 239  
125797 D8SVE8 PAC:15409394 Selaginella moellendorffii 228  
evm.TU.contig_34243.1 PAC:16430424 Carica papaya 225  
evm.TU.contig_35333.1 PAC:16430631 Carica papaya 237  
evm.model.supercontig_1.380 PAC:16404322 Carica papaya 230  
evm.model.supercontig_113.27 PAC:16406036 Carica papaya 267  
evm.model.supercontig_1612.1 PAC:16410224 Carica papaya 214  
evm.model.supercontig_178.28 PAC:16411158 Carica papaya 214  
evm.model.supercontig_2.291 PAC:16412665 Carica papaya 219  
evm.model.supercontig_248.3 PAC:16414659 Carica papaya 729  
evm.model.supercontig_26.249 PAC:16415193 Carica papaya 218  
evm.model.supercontig_3.395 PAC:16416696 Carica papaya 335  
evm.model.supercontig_50.116 PAC:16421573 Carica papaya 215  
evm.model.supercontig_56.64 PAC:16422774 Carica papaya 224  
evm.model.supercontig_56.63 PAC:16422773 Carica papaya 230  
evm.model.supercontig_59.58 PAC:16423197 Carica papaya 221  
evm.model.supercontig_59.59 PAC:16423198 Carica papaya 220  
evm.model.supercontig_59.60 PAC:16423200 Carica papaya 220  
evm.model.supercontig_73.68 PAC:16425649 Carica papaya 140  
evm.model.supercontig_73.67 PAC:16425648 Carica papaya 225  
evm.model.supercontig_73.70 PAC:16425652 Carica papaya 225  
evm.model.supercontig_87.74 PAC:16427745 Carica papaya 225  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9074797
            10783391
            11035031
            10416260
            11327815
            9045797