| Type: | Domain | Name: | BSD domain |
| Description: | The BSD domain is an about 60-residue long domain named after the BTF2-like transcription factors, Synapse-associated proteins and DOS2-like proteins inwhich it is found. Additionally, it is also found in several hypothetical proteins. The BSD domain occurs in one or two copies in a variety of speciesranging from primal protozoan to human. It can be found associated with other domains such as the BTB domain (see ) or the U-box in multidomain proteins. The function of the BSD domain is yet unknown [].Secondary structure prediction indicates the presence of three predicted alpha helices, which probably form a three-helical bundle in small domains. Thethird predicted helix contains neighbouring phenylalanine and tryptophan residues - less common amino acids that are invariant in all the BSD domainsidentified and that are the most striking sequence features of the domain [].Some proteins known to contain one or two BSD domains are listed below: Mammalian TFIIH basal transcription factor complex p62 subunit (GTF2H1).Yeast RNA polymerase II transcription factor B 73 kDa subunit (TFB1), the homologue of BTF2.Yeast DOS2 protein. It is involved in single-copy DNA replication and ubiquitination.Drosophila synapse-associated protein SAP47.Mammalian SYAP1.Various Arabidopsis thaliana(Mouse-ear cress) hypothetical proteins. | Short Name: | BSD_dom |
