| Type: | Domain | Name: | p53/RUNT-type transcription factor, DNA-binding domain |
| Description: | This DNA-binding domain is found in the p53 and the RUNT families of transcription factors. The DNA-binding domain acts to clamp or encircle the DNA target in order to stabilise the protein-DNA complex. This domain has an immunoglobulin-like fold consisting of a beta-sandwich of 9 strands in two sheets with a Greek key topology []. The p53 tumour suppressor functions primarily as a sequence-specific transcription factor, but also has transcription-independent roles in DNA repair and recombination []. In addition, p53, as well as its family members p63 and p73, are involved in the survival/death checkpoint in peripheral and central neurons, where full-length proteins appear to be involved in cell death, and truncated isoforms that retain the DNA-binding domain are involved in cell survival [].RUNT domain (RD) proteins (also known as RUNX, AML, CBF-alpha and PEBP2-alpha) are a family of transcription factors involved in various developmental pathways. The RD has two general functions: it directs the binding of the protein to a target sequence, PyGPyGGTPy (Py=pyrimidine), in order to regulate the expression of target genes; and it mediates protein-protein interactions with CBF-beta which modulates the DNA-binding affinity of the RD []. | Short Name: | p53/RUNT-type_TF_DNA-bd |
| GO Term | Gene Name |
|---|---|
| GO:0003677 | IPR012346 |
| GO:0003700 | IPR012346 |
| GO:0006355 | IPR012346 |
| GO:0005634 | IPR012346 |
| GO Term | Gene Name |
|---|---|
| GO:0003677 | IPR012346 |
| GO:0003700 | IPR012346 |
| GO:0006355 | IPR012346 |
| GO:0005634 | IPR012346 |
| DB identifier | Type | Name |
|---|---|---|
| IPR008967 | Domain | p53-like transcription factor, DNA-binding |
