Protein Domain : IPR030564

Type:  Family Name:  Myotubularin family
Description:  The myotubularin family constitutes a large group of conserved proteins, with 14 members in humans (MTM1, MTMR1-MTMR13). Orthologues have been found throughout the eukaryotic kingdom, but not in bacteria. MTM1 dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) to phosphatidylinositol and phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2] to phosphatidylinositol 5-monophosphate (PI5P) [, ]. The substrate phosphoinositides (PIs) are known to regulate traffic within the endosomal-lysosomal pathway []. MTMR1, MTMR2, MTMR3,MTMR4, and MTMR6 have also been shown to utilise PI(3)P as a substrate, suggesting that this activity is intrinsic to all active family members. On the other hand, six of the MTM family members encode for catalytically inactive phosphatases. Inactive myotubularin phosphatases contain substitutions in the Cys and Arg residues of the Cys-X5-Arg motif. MTM pseudophosphatases have been found to interact with MTM catalytic phosphatases []. The myotubularin family includes several members mutated in neuromuscular diseases or associated with metabolic syndrome, obesity, and cancer []. Short Name:  Myotubularin_fam
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11 Child Features

DB identifier Type Name
IPR030590 Family Myotubularin-related protein 4
IPR030591 Family Myotubularin-related protein 8
IPR030581 Family Myotubularin-related protein 6
IPR030580 Family Myotubularin-related protein 11
IPR030587 Family Myotubularin-related protein 1/2
IPR030572 Family Myotubularin-related protein 7
IPR030573 Family Myotubularin-related protein 10
IPR030576 Family Myotubularin-related protein 12
IPR030574 Family Myotubularin-related protein 5
IPR030561 Family Myotubularin
IPR030567 Family Myotubularin-related protein 13

0 Contains

1 Cross References

Identifier
PTHR10807

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

658 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
437478 D8QR58 PAC:15418311 Selaginella moellendorffii 1780  
evm.TU.contig_33984.1 PAC:16430369 Carica papaya 161  
evm.model.supercontig_942.1 PAC:16428826 Carica papaya 322  
28077.m000082 B9T6R5 PAC:16799890 Ricinus communis 854  
Cucsa.163260.1 PAC:16965799 Cucumis sativus 371  
Cucsa.163230.1 PAC:16965796 Cucumis sativus 576  
orange1.1g047971m PAC:18116402 Citrus sinensis 374  
orange1.1g034396m A0A067D9N0 PAC:18119817 Citrus sinensis 96  
AT3G10550.1 F4J3T8 PAC:19663685 Arabidopsis thaliana 840  
Thhalv10020062m V4M9F6 PAC:20181477 Eutrema salsugineum 841  
Thhalv10012689m V4LD85 PAC:20203216 Eutrema salsugineum 833  
Lus10038641 PAC:23143026 Linum usitatissimum 859  
Lus10037915 PAC:23163692 Linum usitatissimum 815  
Potri.008G026900.4 PAC:27038475 Populus trichocarpa 367  
Potri.008G026900.6 PAC:27038477 Populus trichocarpa 302  
Potri.008G026900.3 PAC:27038474 Populus trichocarpa 524  
Potri.008G026900.2 A0A2K1ZAN5 PAC:27038473 Populus trichocarpa 857  
Potri.008G026900.5 PAC:27038476 Populus trichocarpa 302  
Potri.008G026900.1 A0A2K1ZAN2 PAC:27038472 Populus trichocarpa 859  
Potri.010G233600.2 A0A2K1YZ43 PAC:26982257 Populus trichocarpa 857  
Potri.010G233600.4 A0A2K1YZ35 PAC:26982259 Populus trichocarpa 570  
Potri.010G233600.1 PAC:26982256 Populus trichocarpa 858  
Potri.010G233600.3 A0A2K1YZ35 PAC:26982258 Populus trichocarpa 570  
Gorai.002G144900.3 A0A0D2QCY6 PAC:26793798 Gossypium raimondii 711  
Gorai.002G144900.2 A0A0D2R617 PAC:26793796 Gossypium raimondii 846  
Gorai.008G097500.1 A0A0D2SY25 PAC:26815212 Gossypium raimondii 847  
Thecc1EG043552t1 A0A061FPH8 PAC:27442361 Theobroma cacao 849  
Migut.F01661.1.p PAC:28932343 Mimulus guttatus 847  
Araha.6120s0006.1.p PAC:28858059 Arabidopsis halleri 833  
Araha.7226s0007.1.p PAC:28849308 Arabidopsis halleri 846  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            16828287
            16787938
            10900271
            11001925
            22578719