Protein Domain : IPR014712

Type:  Domain Name:  Phosphoinositide-binding clathrin adaptor, domain 2
Description:  Clathrin-mediated endocytosis plays an important role in retrieving synaptic vesicles from the plasma membrane following exocytosis, and requires the action of CALM (clathrin assembly lymphoid myeloid leukemia protein) or its homologue AP180 (adaptor protein 180) [, ]. These proteins act to restrict the size of the clathrin-coated vesicles. The phosphoinositide-binding domain regulates the clathrin assembly activity of these proteins. Phosphoinositides control the timing and localisation of endocytic membrane trafficking by recruiting adaptors and other components of the transport machinery, thereby being part of a coincidence detection system in adaptor-mediated vesicle transport [].The N-terminal phosphoinositide-binding domain of CALM and AP180 consist of nine alpha helices forming a solenoid structure. This is most similar to the ENTH domain of epsin, with the first seven helices of epsin superimposing well on those of CALM. However, in epsin the final alpha8 helix folds back across the others, whereas in CALM and AP180 the final three long helices continue the solenoidal pattern []. This entry represents this 3-helical closed bundle structural subdomain found in CALM and AP180.This domain that shares structural similarity with the GAT domain (). It is usually found C-terminal to the the ENTH-like domain (). Short Name:  Clathrin_AP_2
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0 Child Features

0 Contains

1 Cross References

Identifier
G3DSA:1.20.58.150

1 Found In

DB identifier Type Name
IPR011417 Domain AP180 N-terminal homology (ANTH) domain

4 GO Annotations

GO Term Gene Name
GO:0005545 IPR014712
GO:0030276 IPR014712
GO:0048268 IPR014712
GO:0030136 IPR014712

4 Ontology Annotations

GO Term Gene Name
GO:0005545 IPR014712
GO:0030276 IPR014712
GO:0048268 IPR014712
GO:0030136 IPR014712

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
230819 D8R670 PAC:15416851 Selaginella moellendorffii 547  
437722 D8QP51 PAC:15420495 Selaginella moellendorffii 601  
440070 D8R9W6 PAC:15401959 Selaginella moellendorffii 596  
evm.TU.contig_40037.1 PAC:16431428 Carica papaya 147  
evm.model.supercontig_132.22 PAC:16408116 Carica papaya 613  
evm.model.supercontig_2.122 PAC:16412478 Carica papaya 378  
evm.model.supercontig_2.235 PAC:16412603 Carica papaya 564  
evm.model.supercontig_21.225 PAC:16413509 Carica papaya 419  
evm.model.supercontig_46.25 PAC:16420489 Carica papaya 625  
evm.model.supercontig_845.2 PAC:16427394 Carica papaya 580  
evm.model.supercontig_95.13 PAC:16428851 Carica papaya 541  
evm.model.supercontig_954.1 PAC:16428936 Carica papaya 640  
29780.m001392 B9S7D9 PAC:16808423 Ricinus communis 379  
29848.m004618 B9RP36 PAC:16811273 Ricinus communis 662  
29948.m000714 B9SH67 PAC:16814379 Ricinus communis 634  
29968.m000647 B9SNG6 PAC:16814631 Ricinus communis 454  
30094.m000673 B9SCP6 PAC:16817590 Ricinus communis 578  
29671.m000298 B9SP87 PAC:16805284 Ricinus communis 566  
28543.m000389 B9T128 PAC:16801068 Ricinus communis 548  
29692.m000533 B9SP68 PAC:16805919 Ricinus communis 567  
27622.m000151 B9T5B4 PAC:16798829 Ricinus communis 555  
Cucsa.398770.1 PAC:16983628 Cucumis sativus 387  
Cucsa.009230.1 PAC:16951276 Cucumis sativus 225  
Cucsa.009210.1 PAC:16951274 Cucumis sativus 318  
Cucsa.185080.1 PAC:16967646 Cucumis sativus 554  
Cucsa.310310.1 PAC:16976512 Cucumis sativus 653  
Cucsa.345810.1 PAC:16979548 Cucumis sativus 618  
orange1.1g035209m A0A067DCL9 PAC:18108538 Citrus sinensis 70  
orange1.1g009078m A0A067G1J8 PAC:18125742 Citrus sinensis 544  
orange1.1g009073m A0A067G1J8 PAC:18125743 Citrus sinensis 544  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11239400
            11161218
            16246100