Protein Domain : IPR007365

Type:  Domain Name:  Transferrin receptor-like, dimerisation domain
Description:  This entry represents the dimerisation domain found in the transferrin receptor, as well as in a number of other proteins including glutamate carboxypeptidase II and N-acetylated-alpha-linked acidic dipeptidase like protein.The transferrin receptor (TfR) assists iron uptake into vertebrate cells through a cycle of endo- and exocytosis of the iron transport protein transferrin (Tf). TfR binds iron-loaded (diferric) Tf at the cell surface and carries it to the endosome, where the iron dissociates from Tf. The apo-Tf remains bound to TfR until it reaches the cell surface, where apo-Tf is replaced by diferric Tf from the serum to begin the cycle again. Human TfR is a homodimeric type II transmembrane protein. The crystal structure of a TfR monomer reveals a 3-domain structure: a protease-like domain that closely resembles carboxy- and amino-peptidases; an apical domain consisting of a beta-sandwich; and a helical dimerisation domain. The dimerisation domain consists of a 4-helical bundle that makes contact with each of the three domains in the dimer partner []. Short Name:  TFR-like_dimer_dom

0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF04253
G3DSA:1.20.930.40
SSF47672

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
81471 D8QZ02 PAC:15408275 Selaginella moellendorffii 703  
421595 D8SFR8 PAC:15416672 Selaginella moellendorffii 783  
61589 D8QN97 PAC:15417094 Selaginella moellendorffii 641  
73556 D8QPJ3 PAC:15407614 Selaginella moellendorffii 690  
87649 D8R6X7 PAC:15404948 Selaginella moellendorffii 616  
61588 D8R6X9 PAC:15417092 Selaginella moellendorffii 634  
evm.model.supercontig_222.2 PAC:16413988 Carica papaya 522  
29912.m005425 B9RKG5 PAC:16813302 Ricinus communis 648  
29333.m001105 B9SDP7 PAC:16802717 Ricinus communis 709  
27894.m000794 B9SEW1 PAC:16799432 Ricinus communis 120  
Cucsa.242290.1 PAC:16971145 Cucumis sativus 688  
orange1.1g005260m A0A067FGW4 PAC:18116644 Citrus sinensis 705  
orange1.1g005347m A0A067FGT2 PAC:18116645 Citrus sinensis 701  
AT5G19740.1 Q7Y228 PAC:19666554 Arabidopsis thaliana 681  
AT3G54720.1 Q9M1S8 PAC:19660452 Arabidopsis thaliana 705  
AT1G64330.1 Q9C7V7 PAC:19657584 Arabidopsis thaliana 555  
Thhalv10010161m V4LRC1 PAC:20207201 Eutrema salsugineum 713  
Thhalv10012881m V4LQA1 PAC:20204235 Eutrema salsugineum 673  
Ciclev10011190m V4SW42 PAC:20797700 Citrus clementina 708  
Ciclev10007621m V4UQ18 PAC:20794872 Citrus clementina 705  
Lus10017223 PAC:23165865 Linum usitatissimum 544  
Lus10021090 PAC:23182325 Linum usitatissimum 561  
Lus10011133 PAC:23167519 Linum usitatissimum 658  
Lus10001547 PAC:23170459 Linum usitatissimum 317  
Lus10043036 PAC:23167942 Linum usitatissimum 628  
Potri.016G064300.1 PAC:27011953 Populus trichocarpa 717  
Potri.016G064300.2 A0A2K1XBM9 PAC:27011954 Populus trichocarpa 704  
Potri.006G153300.1 PAC:27004122 Populus trichocarpa 646  
Potri.006G198400.1 A0A2K2A4Z9 PAC:27006634 Populus trichocarpa 243  
Gorai.001G099300.4 A0A0D2PPE3 PAC:26823873 Gossypium raimondii 663  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10531064