Protein Domain : IPR001044

Type:  Family Name:  XPG/Rad2 endonuclease, eukaryotes
Description:  This entry represents XPG (also known as Rad2 in budding yeast, AtRAD2 or UVH3 in Arabidopsis and Rad13 in fission yeast), a single-stranded structure-specific DNA endonuclease, which cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA []. In Saccharomyces cerevisiae, Rad2 forms the Nucleotide Excision Repair Factor 3 (NEF3) complex with a subset of subunits of the transcription factor TFIIH []. Besides DNA damage repair, it is also required for efficient transcription []. Defects in XPG are the cause of xeroderma pigmentosum complementation group G (XP-G), which is an autosomal recessive pigmentary skin disorder characterised by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities []. Short Name:  XPG/Rad2_eukaryotes
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0 Child Features

4 Contains

DB identifier Type Name
IPR020045 Domain 5'-3' exonuclease, C-terminal domain
IPR006086 Domain XPG-I domain
IPR008918 Conserved_site Helix-hairpin-helix motif, class 2
IPR019974 Conserved_site XPG conserved site

3 Cross Referencess

Identifier
PTHR11081:SF1
PR00066
TIGR00600

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0003697 IPR001044
GO:0004519 IPR001044
GO:0006289 IPR001044
GO:0005634 IPR001044

4 Ontology Annotations

GO Term Gene Name
GO:0003697 IPR001044
GO:0004519 IPR001044
GO:0006289 IPR001044
GO:0005634 IPR001044

1 Parent Features

DB identifier Type Name
IPR006084 Family XPG/Rad2 endonuclease

732 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
73710 D8QQY4 PAC:15409158 Selaginella moellendorffii 116  
evm.model.supercontig_140.35 PAC:16408880 Carica papaya 333  
evm.model.supercontig_140.34 PAC:16408879 Carica papaya 868  
29822.m003372 B9RUC5 PAC:16809742 Ricinus communis 1641  
Cucsa.339510.1 PAC:16978892 Cucumis sativus 1462  
orange1.1g000457m PAC:18123042 Citrus sinensis 1484  
orange1.1g000456m PAC:18123041 Citrus sinensis 1484  
AT3G28030.1 Q9ATY5 PAC:19663975 Arabidopsis thaliana 1479  
Thhalv10003517m V4KYZ5 PAC:20198429 Eutrema salsugineum 1480  
Ciclev10014063m V4TH41 PAC:20817994 Citrus clementina 1250  
Ciclev10014025m V4U1F1 PAC:20817993 Citrus clementina 1699  
Lus10039423 PAC:23175574 Linum usitatissimum 267  
Lus10039424 PAC:23175617 Linum usitatissimum 1406  
Potri.017G070500.1 A0A2K1X4D8 PAC:26984769 Populus trichocarpa 1691  
Gorai.001G260400.1 A0A0D2PX24 PAC:26821708 Gossypium raimondii 1700  
Gorai.001G260400.4 A0A0D2Q4K9 PAC:26821713 Gossypium raimondii 1635  
Gorai.001G260400.3 A0A0D2QW74 PAC:26821711 Gossypium raimondii 1667  
Gorai.001G260400.6 A0A0D2NEH1 PAC:26821714 Gossypium raimondii 1470  
Gorai.001G260400.7 A0A0D2M3C8 PAC:26821712 Gossypium raimondii 1666  
Gorai.001G260400.5 A0A0D2QW79 PAC:26821709 Gossypium raimondii 1696  
Gorai.001G260400.2 A0A0D2Q4K5 PAC:26821710 Gossypium raimondii 1669  
6698 I0YVW2 PAC:27388864 Coccomyxa subellipsoidea C-169 262  
9431 I0YVW1 PAC:27388845 Coccomyxa subellipsoidea C-169 116  
12635 C1MGU5 PAC:27346011 Micromonas pusilla CCMP1545 125  
10761 C1MGU6 PAC:27345340 Micromonas pusilla CCMP1545 237  
55373 C1FEA4 PAC:27399211 Micromonas sp RCC299 1108  
3874 A4S5U0 PAC:27417005 Ostreococcus lucimarinus 271  
Thecc1EG016845t1 A0A061ECG6 PAC:27451865 Theobroma cacao 1670  
Thecc1EG016845t3 A0A061EBG8 PAC:27451867 Theobroma cacao 1215  
Thecc1EG016845t2 A0A061EJ65 PAC:27451866 Theobroma cacao 1239  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            22863773
            7951246
            8855246
            12110180