Protein Domain : IPR000133

Type:  Family Name:  ER lumen protein retaining receptor
Description:  Proteins resident in the lumen of the endoplasmic reticulum (ER) contain a C-terminal tetrapeptide, commonly known as Lys-Asp-Glu-Leu (KDEL) in mammals and His-Asp-Glu-Leu(HDEL) in yeast (Saccharomyces cerevisiae) that acts as a signal for their retrieval from subsequent compartments of the secretory pathway. The receptor for this signal is a ~26 kDa Golgimembrane protein, initially identified as the ERD2 gene product in S. cerevisiae. The receptor molecule, known variously as the ER lumen protein retaining receptor or the'KDEL receptor', is believed to cycle between the cis side of the Golgi apparatus and the ER. It has also been characterised in a number of other species, including plants,Plasmodium, Drosophila and mammals. In mammals, 2 highly related forms of the receptor are known. The KDEL receptor is a highly hydrophobic protein of 220 residues; its sequence exhibits 7 hydrophobic regions, all of which have been suggested to traverse themembrane []. More recently, however, it has been suggested that only 6 of theseregions are transmembrane (TM), resulting in both N- and C-termini on the cytoplasmic side of the membrane. Short Name:  ER_ret_rcpt

0 Child Features

0 Contains

5 Cross Referencess

Identifier
PTHR10585
PF00810
PR00660
PS00951
PS00952

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0046923 IPR000133
GO:0006621 IPR000133
GO:0016021 IPR000133

3 Ontology Annotations

GO Term Gene Name
GO:0046923 IPR000133
GO:0006621 IPR000133
GO:0016021 IPR000133

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
162537 D8TAU3 PAC:15405327 Selaginella moellendorffii 284  
115638 D8SF76 PAC:15423515 Selaginella moellendorffii 273  
143476 D8R3Y6 PAC:15415649 Selaginella moellendorffii 215  
75833 D8QPH2 PAC:15415863 Selaginella moellendorffii 215  
evm.model.supercontig_26.41 PAC:16415282 Carica papaya 272  
evm.model.supercontig_37.199 PAC:16418657 Carica papaya 254  
evm.model.supercontig_428.5 PAC:16419900 Carica papaya 273  
evm.model.supercontig_7.117 PAC:16425017 Carica papaya 215  
evm.model.supercontig_8.138 PAC:16426417 Carica papaya 215  
29711.m000331 B9STD7 PAC:16806462 Ricinus communis 272  
29904.m002932 B9RWG5 PAC:16812577 Ricinus communis 206  
30026.m001475 B9S8E2 PAC:16815860 Ricinus communis 215  
30073.m002241 B9S200 PAC:16816826 Ricinus communis 215  
30120.m000373 B9SYM6 PAC:16818090 Ricinus communis 255  
30170.m014183 B9R890 PAC:16822017 Ricinus communis 221  
Cucsa.343040.3 PAC:16979484 Cucumis sativus 207  
Cucsa.343040.1 A0A0A0LJ62 PAC:16979482 Cucumis sativus 272  
Cucsa.343040.2 PAC:16979483 Cucumis sativus 238  
Cucsa.047150.6 PAC:16953625 Cucumis sativus 153  
Cucsa.047150.1 A0A0A0KIB4 PAC:16953620 Cucumis sativus 215  
Cucsa.047150.2 PAC:16953621 Cucumis sativus 206  
Cucsa.047150.3 PAC:16953622 Cucumis sativus 206  
Cucsa.047150.4 PAC:16953623 Cucumis sativus 206  
Cucsa.047150.5 PAC:16953624 Cucumis sativus 206  
Cucsa.150060.1 PAC:16964384 Cucumis sativus 287  
Cucsa.150200.1 A0A0A0L8S9 PAC:16964397 Cucumis sativus 215  
Cucsa.169280.1 A0A0A0LPJ8 PAC:16966376 Cucumis sativus 272  
Cucsa.159870.1 A0A0A0LRN5 PAC:16965268 Cucumis sativus 273  
Cucsa.159880.2 PAC:16965269 Cucumis sativus 246  
Cucsa.193970.1 A0A0A0LI81 PAC:16968121 Cucumis sativus 215  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8392934