Type: | Domain | Name: | Alpha-ketoglutarate-dependent dioxygenase AlkB-like |
Description: | AlkB is a DNA repair enzyme that removes methyl adducts and some larger alkylation lesions from endocyclic positions on purine and pyrimidine bases. It is a dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron [, ]. The catalytic core of AlkB is homologous to other Fe-2OG dioxygenases []. Two discrete global conformations have been observed for AlkB, differing in accessibility of a putative oxygen-diffusion tunnel []. | Short Name: | AlkB-like |