Protein Domain : IPR023797

Type:  Domain Name:  RNA 3'-terminal phosphate cyclase domain
Description:  RNA cyclases are a family of RNA-modifying enzymes that are conserved in eukaryotes, bacteria and archaea. Type 1 RNA 3'-terminal phosphate cyclases () [, ] catalyse the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA:ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate The physiological function of the cyclase is not known, but the enzyme could be involved in the maintenance of cyclic ends in tRNA splicing intermediates or in the cyclisation of the 3' end of U6 snRNA [].A second subfamily of RNA 3'-terminal phosphate cyclases (type 2) that do not have cyclase activity have been identified in eukaryotes. They are localised to the nucleolus and are involved in ribosomal modification [].The crystal structure of RNA 3'-terminal phosphate cyclase shows that each molecule consists of two domains. The larger domain contains three repeats of a folding unit comprising two parallel alpha helices and a four-stranded beta sheet; this fold was previously identified in translation initiation factor 3 (IF3).The large domain is similar to one of the two domains of 5-enolpyruvylshikimate-3-phosphate synthase and UDP-N-acetylglucosamine enolpyruvyl transferase. The smaller domain uses asimilar secondary structure element with different topology, observed in many other proteins such as thioredoxin []. Although the active site of this enzyme has not beenunambiguously assigned, it can be mapped to a region surrounding His309, an adenylate acceptor, in which a number of amino acids are highly conserved in the enzyme from differentsources []. Short Name:  RNA3'_phos_cyclase_dom

0 Child Features

0 Contains

2 Cross Referencess

Identifier
PF01137
G3DSA:3.65.10.20

0 Found In

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR013792 Domain RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta

711 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
411609 D8RIH3 PAC:15410075 Selaginella moellendorffii 236  
411685 D8RIQ2 PAC:15410280 Selaginella moellendorffii 200  
411741 D8RIW6 PAC:15410963 Selaginella moellendorffii 1167  
94929 D8RIV3 PAC:15405658 Selaginella moellendorffii 131  
138341 D8TF30 PAC:15422044 Selaginella moellendorffii 131  
4441 D8QV12 PAC:15415861 Selaginella moellendorffii 195  
173778 D8RS79 PAC:15417166 Selaginella moellendorffii 360  
419363 D8S8P4 PAC:15408903 Selaginella moellendorffii 438  
439076 D8R2A0 PAC:15421017 Selaginella moellendorffii 201  
428048 D8T1J1 PAC:15410959 Selaginella moellendorffii 153  
127200 D8SXR9 PAC:15411255 Selaginella moellendorffii 131  
3085 D8QRF1 PAC:15409929 Selaginella moellendorffii 337  
76880 D8QS46 PAC:15418893 Selaginella moellendorffii 168  
evm.model.supercontig_56.89 PAC:16422801 Carica papaya 377  
evm.model.supercontig_59.79 PAC:16423220 Carica papaya 182  
28095.m000097 B9T7D2 PAC:16799926 Ricinus communis 377  
Cucsa.355940.1 A0A0A0LXL4 PAC:16980240 Cucumis sativus 377  
orange1.1g017072m A0A067DYB6 PAC:18101279 Citrus sinensis 378  
AT5G22100.1 Q9C578 PAC:19668850 Arabidopsis thaliana 375  
Thhalv10013826m V4LQP6 PAC:20205932 Eutrema salsugineum 378  
Thhalv10028736m V4LG18 PAC:20197270 Eutrema salsugineum 377  
Thhalv10029476m V4L6L2 PAC:20197538 Eutrema salsugineum 347  
Ciclev10028663m V4RRZ7 PAC:20812438 Citrus clementina 378  
Lus10004092 PAC:23147803 Linum usitatissimum 377  
Lus10013351 PAC:23151410 Linum usitatissimum 377  
Potri.009G016000.2 A0A2K1Z178 PAC:26986754 Populus trichocarpa 323  
Potri.009G016000.1 A0A2K1Z177 PAC:26986753 Populus trichocarpa 376  
Potri.009G016000.3 PAC:26986755 Populus trichocarpa 297  
Potri.001G216400.1 B9GHM4 PAC:27045300 Populus trichocarpa 376  
Gorai.006G116200.1 A0A0D2SVX2 PAC:26830732 Gossypium raimondii 378  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9184239
            2199762
            10790377
            10673421