Protein Domain : IPR007185

Type:  Domain Name:  DNA polymerase alpha/epsilon, subunit B
Description:  DNA polymerase epsilon is essential for cell viability and chromosomal DNA replication in budding yeast. In addition, DNA polymerase epsilon may be involved in DNA repair and cell-cycle checkpoint control. The enzyme consists of at least four subunits in mammalian cells as well as in yeast. The largest subunit of DNA polymerase epsilon is responsible for polymerase activity. In mouse, the DNA polymerase epsilon subunit B is the second largest subunit of the DNA polymerase. A part of the N-terminal was found to be responsible for the interaction with SAP18. Experimental evidence suggests that this subunit may recruit histone deacetylase to the replication fork to modify the chromatin structure []. Short Name:  DNA_pol_alpha/epsilon_bsu

0 Child Features

0 Contains

1 Cross References

Identifier
PF04042

2 Found Ins

DB identifier Type Name
IPR016266 Family DNA polymerase epsilon, subunit B
IPR016722 Family DNA polymerase alpha, subunit B

3 GO Annotations

GO Term Gene Name
GO:0003677 IPR007185
GO:0003887 IPR007185
GO:0006260 IPR007185

3 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR007185
GO:0003887 IPR007185
GO:0006260 IPR007185

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
441552 D8RKL2 PAC:15408601 Selaginella moellendorffii 427  
236823 D8TE04 PAC:15412080 Selaginella moellendorffii 523  
23326 D8TEH3 PAC:15414874 Selaginella moellendorffii 241  
110038 D8S6E2 PAC:15404282 Selaginella moellendorffii 590  
111965 D8S9Z8 PAC:15414357 Selaginella moellendorffii 484  
125908 D8SVI7 PAC:15410763 Selaginella moellendorffii 442  
403984 D8QT72 PAC:15411236 Selaginella moellendorffii 134  
evm.model.supercontig_103.12 PAC:16404894 Carica papaya 489  
evm.model.supercontig_43.8 PAC:16420041 Carica papaya 620  
evm.model.supercontig_85.67 PAC:16427504 Carica papaya 440  
29929.m004734 B9RMM9 PAC:16813973 Ricinus communis 621  
29613.m000361 B9SXI8 PAC:16803696 Ricinus communis 425  
27934.m000196 B9SYF4 PAC:16799536 Ricinus communis 536  
Cucsa.054690.1 PAC:16954434 Cucumis sativus 483  
Cucsa.113370.1 PAC:16960315 Cucumis sativus 635  
Cucsa.242680.1 A0A0A0LF21 PAC:16971200 Cucumis sativus 438  
orange1.1g013632m PAC:18118164 Citrus sinensis 439  
orange1.1g009713m A0A067DVL2 PAC:18135451 Citrus sinensis 528  
orange1.1g014802m A0A067DUC4 PAC:18135452 Citrus sinensis 418  
orange1.1g006976m PAC:18102429 Citrus sinensis 623  
AT5G22110.1 Q500V9 PAC:19667785 Arabidopsis thaliana 526  
AT1G67630.1 F4HTP2 PAC:19655786 Arabidopsis thaliana 620  
AT2G42120.2 O48520 PAC:19640406 Arabidopsis thaliana 440  
AT2G42120.1 F4IM00 PAC:19640405 Arabidopsis thaliana 441  
Thhalv10016664m V4M9A6 PAC:20179967 Eutrema salsugineum 441  
Thhalv10001961m V4M5A7 PAC:20200553 Eutrema salsugineum 522  
Thhalv10018287m V4KBR8 PAC:20192314 Eutrema salsugineum 622  
Ciclev10012767m V4S6M2 PAC:20798798 Citrus clementina 209  
Ciclev10019690m V4T327 PAC:20810715 Citrus clementina 528  
Ciclev10020334m V4TME9 PAC:20810716 Citrus clementina 418  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11872158