Protein Domain : IPR002694

Type:  Domain Name:  Zinc finger, CHC2-type
Description:  Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt bridges to stabilise the finger-like folds. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis(African clawed frog), however they are now recognised to bind DNA, RNA, protein and/or lipid substrates [, , , , ]. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superfamilies of Znf motifs, varying in both sequence and structure. They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. For example, Znf-containing proteins function in gene transcription, translation, mRNA trafficking, cytoskeleton organisation, epithelial development, cell adhesion, protein folding, chromatin remodelling and zinc sensing, to name but a few []. Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. This entry represents CycHisCysCys (CHC2) type zinc finger domains, which are found in bacteria and viruses. Short Name:  Znf_CHC2
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0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF01807
SM00400
G3DSA:3.90.580.10

1 Found In

DB identifier Type Name
IPR006295 Domain DNA primase, DnaG

4 GO Annotations

GO Term Gene Name
GO:0003677 IPR002694
GO:0003896 IPR002694
GO:0008270 IPR002694
GO:0006260 IPR002694

4 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR002694
GO:0003896 IPR002694
GO:0008270 IPR002694
GO:0006260 IPR002694

0 Parent Features

145 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
406467 D8R2G1 PAC:15416130 Selaginella moellendorffii 515  
403990 D8QT78 PAC:15411254 Selaginella moellendorffii 557  
Cucsa.367200.1 A0A0A0LJM4 PAC:16981636 Cucumis sativus 561  
Cucsa.163790.2 PAC:16965849 Cucumis sativus 847  
Cucsa.163790.1 PAC:16965848 Cucumis sativus 847  
Cucsa.163790.3 PAC:16965850 Cucumis sativus 847  
Araha.11756s0303.1.p PAC:28856361 Arabidopsis halleri 627  
Bostr.15654s0015.1.p PAC:30680356 Boechera stricta 153  
Medtr2g014170.1 G7ISD2 PAC:31062814 Medicago truncatula 309  
Medtr4g094350.1 A0A072UN94 PAC:31110778 Medicago truncatula 54  
Medtr0715s0010.1 A0A072TDJ0 PAC:31061822 Medicago truncatula 386  
Prupe.5G027600.1.p M5WFG4 PAC:32096449 Prunus persica 515  
Prupe.5G027600.2.p M5WFG4 PAC:32096450 Prunus persica 515  
GSMUA_Achr6P25500_001 PAC:32321213 Musa acuminata 463  
Manes.07G043000.3.p A0A2C9VID2 PAC:32352931 Manihot esculenta 294  
Manes.07G043100.1.p A0A2C9VII5 PAC:32353677 Manihot esculenta 590  
Kalax.0004s0053.1.p PAC:32539695 Kalanchoe laxiflora 926  
Kalax.0414s0031.2.p PAC:32590165 Kalanchoe laxiflora 917  
Kalax.0414s0031.1.p PAC:32590164 Kalanchoe laxiflora 917  
Mapoly0001s0220.1.p A0A2R6XVS3 PAC:33020005 Marchantia polymorpha 158  
Aqcoe7G348800.5.p PAC:33073883 Aquilegia coerulea 410  
Aqcoe5G269600.1.p A0A2G5C9T6 PAC:33085411 Aquilegia coerulea 470  
Aqcoe5G269600.2.p PAC:33085412 Aquilegia coerulea 396  
Aqcoe1G317200.1.p A0A2G5CH95 PAC:33079447 Aquilegia coerulea 227  
LOC_Os03g37680.1 PAC:33132378 Oryza sativa 231  
Dusal.0091s00007.1.p PAC:33193985 Dunaliella salina 81  
Brdisv1BdTR7a1016654m.p PAC:33361614 Brachypodium distachyon BdTR7a 726  
Brdisv1ABR9_r1024607m.p PAC:33544350 Brachypodium distachyon ABR9 325  
Brdisv1ABR9_r1034586m.p PAC:33551469 Brachypodium distachyon ABR9 78  
Brdisv1Mon31043805m.p PAC:34305311 Brachypodium distachyon Mon3 717  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12665246
            15718139
            17210253
            15963892
            10529348
            11179890