3 Ontology Annotations
GO Term | Gene Name |
---|---|
GO:0003746 | IPR001816 |
GO:0006414 | IPR001816 |
GO:0005622 | IPR001816 |
Type: | Family | Name: | Translation elongation factor EFTs/EF1B |
Description: | Translation elongation factors are responsible for two main processes during protein synthesis on the ribosome [, , ]. EF1A (or EF-Tu) is responsible for the selection and binding of the cognate aminoacyl-tRNA to the A-site (acceptor site) of the ribosome. EF2 (or EF-G) is responsible for the translocation of the peptidyl-tRNA from the A-site to the P-site (peptidyl-tRNA site) of the ribosome, thereby freeing the A-site for the next aminoacyl-tRNA to bind. Elongation factors are responsible for achieving accuracy of translation and both EF1A and EF2 are remarkably conserved throughout evolution.Elongation factor EF1B (also known as EF-Ts or EF-1beta/gamma/delta) is a nucleotide exchange factor that is required to regenerate EF1A from its inactive form (EF1A-GDP) to its active form (EF1A-GTP). EF1A is then ready to interact with a new aminoacyl-tRNA to begin the cycle again. EF1B is more complex in eukaryotes than in bacteria, and can consist of three subunits: EF1B-alpha (or EF-1beta), EF1B-gamma (or EF-1gamma) and EF1B-beta (or EF-1delta) [].This entry represents EF-Tu (EF1A) proteins found primarily in bacteria, mitochondria and chloroplasts. | Short Name: | Transl_elong_EFTs/EF1B |
GO Term | Gene Name |
---|---|
GO:0003746 | IPR001816 |
GO:0006414 | IPR001816 |
GO:0005622 | IPR001816 |