Protein Domain : IPR030382

Type:  Domain Name:  SAM-dependent methyltransferase TRM5/TYW2-type
Description:  This entry represents a domain found in the Trm5/Tyw2-type methyltransferase. Trm5 and Tyw2 are S-adenosylmethionine-dependent methyltransferases involved in tRNA methylation []. Wybutosine synthesis is a multienzymatic process that comprises six sequential enzymatic reactions involving five enzymes. The initial step, the formation of m1G-37 (guanosine-37 methylated in the N1 position) in precursor tRNAPhe is catalysed by tRNA wybutosine-synthesising protein 5 (Trm5). Tyw2 catalyses the second step, consisting of the alpha-amino-alpha-carboxypropyl (acp) group being transferred from S-AdoMet to the side chain at the C7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86 []. Short Name:  MeTrfase_TRM5/TYW2
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PF02475
PS51684

0 Found In

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR029063 Domain S-adenosyl-L-methionine-dependent methyltransferase

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
102633 D8RV34 PAC:15407521 Selaginella moellendorffii 452  
105763 D8S0R2 PAC:15417245 Selaginella moellendorffii 230  
77358 D8QTH9 PAC:15417877 Selaginella moellendorffii 444  
76241 D8QRK6 PAC:15414258 Selaginella moellendorffii 205  
evm.model.supercontig_12.18 PAC:16406725 Carica papaya 542  
evm.model.supercontig_152.15 PAC:16409597 Carica papaya 1007  
evm.model.supercontig_23.143 PAC:16414192 Carica papaya 320  
29842.m003593 B9RXL2 PAC:16810725 Ricinus communis 1050  
29848.m004687 B9RPA5 PAC:16811342 Ricinus communis 544  
30027.m000848 B9SIH1 PAC:16815941 Ricinus communis 641  
Cucsa.352230.1 A0A0A0L4V8 PAC:16979976 Cucumis sativus 788  
Cucsa.045240.1 PAC:16953332 Cucumis sativus 1038  
Cucsa.045240.2 PAC:16953333 Cucumis sativus 734  
Cucsa.116210.1 PAC:16960526 Cucumis sativus 470  
orange1.1g036185m A0A067GF57 PAC:18112566 Citrus sinensis 1057  
orange1.1g007525m PAC:18130771 Citrus sinensis 600  
orange1.1g045638m PAC:18130724 Citrus sinensis 437  
orange1.1g012998m A0A067EVJ2 PAC:18114061 Citrus sinensis 451  
orange1.1g046527m A0A067GY84 PAC:18096737 Citrus sinensis 380  
AT4G04670.1 Q8W4K1 PAC:19646918 Arabidopsis thaliana 995  
AT4G27340.1 Q6NQ64 PAC:19643749 Arabidopsis thaliana 619  
AT3G56120.1 Q93YU6 PAC:19660389 Arabidopsis thaliana 468  
AT1G30550.2 F4I6D1 PAC:19649779 Arabidopsis thaliana 221  
AT1G30550.1 Q9S9P4 PAC:19649778 Arabidopsis thaliana 455  
Thhalv10024701m V4P508 PAC:20194550 Eutrema salsugineum 610  
Thhalv10005971m V4LL62 PAC:20190627 Eutrema salsugineum 447  
Thhalv10028391m V4L3B5 PAC:20197232 Eutrema salsugineum 1007  
Thhalv10008708m V4KR80 PAC:20186972 Eutrema salsugineum 223  
Ciclev10007807m V4WF95 PAC:20792595 Citrus clementina 591  
Ciclev10008679m V4ULZ4 PAC:20793287 Citrus clementina 374  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            16642040
            20382657