| Type: | Domain | Name: | PUA domain |
| Description: | The PUA (PseudoUridine synthase and Archaeosine transglycosylase) domain was named after the proteins in which it was first found []. PUA is a highly conserved RNA-binding motif found in a wide range of archaeal, bacterial and eukaryotic proteins, including enzymes that catalyse tRNA and rRNA post-transcriptional modifications, proteins involved in ribosome biogenesis and translation, as well as in enzymes involved in proline biosynthesis [, ]. The structures of several PUA-RNA complexes reveal a common RNA recognition surface, but also some versatility in the way in which the motif binds to RNA []. PUA motifs are involved in dyskeratosis congenita and cancer, pointing to links between RNA metabolism and human diseases []. | Short Name: | PUA |
| DB identifier | Type | Name |
|---|---|---|
| IPR004802 | Family | tRNA pseudouridine synthase B family |
| IPR005155 | Family | Ribosome biogenesis factor NIP7-like |
| IPR005715 | Family | Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase |
| IPR011529 | Family | Glutamate 5-kinase |
| IPR016686 | Family | Ribosome biogenesis factor, NIP7 |
| IPR022430 | Family | Conserved hypothetical protein CHP03684 |
| IPR004804 | Family | tRNA-guanine(15) transglycosylase |
