Type: | Domain | Name: | Acetyl-coenzyme A carboxyltransferase, N-terminal |
Description: | Acetyl-coenzyme A carboxylase () (ACC), a member of the biotin-dependent enzyme family, catalyses the formation of malonyl-coenzyme A(CoA) and regulates fatty acid biosynthesis and oxidation. Biotin-dependent carboxylase enzymes perform a two step reaction: enzyme-bound biotin is firstcarboxylated by bicarbonate and ATP and the carboxyl group temporarily bound to biotin is subsequently transferred to an acceptor substrate such asacetyl-CoA. The carboxyltransferase domain performs the second part of the reaction [, ].The N- and C-terminal regions of the carboxyltransferase domain share similar polypeptide backbone folds, with a central beta-beta-alpha superhelix []. The CoA molecule is mostly associated with the N subdomain.In bacterial acetyl coenzyme A carboxylase the N and C subdomains are encoded by two different polypeptides.This entry represents the N-terminal subdomain and contains the bacterial ACC beta-subunit. | Short Name: | COA_CT_N |