Protein Domain : IPR001296

Type:  Domain Name:  Glycosyl transferase, family 1
Description:  The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. A classification of glycosyltransferases using nucleotide diphospho-sugar, nucleotide monophospho-sugar and sugar phosphates () and related proteins into distinct sequence based families has been described []. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. The same three-dimensional fold is expected to occur within each of the families. Because 3-D structures are better conserved than sequences, several of the families defined on the basis of sequence similarities may have similar 3-D structures and therefore form 'clans'.Proteins containign this domain transfer UDP, ADP, GDP or CMP linked sugars to a variety of substrates, including glycogen, fructose-6-phosphate and lipopolysaccharides. The bacterial enzymes are involved in various biosynthetic processes that include exopolysaccharide biosynthesis, lipopolysaccharide core biosynthesis and the biosynthesisof the slime polysaccaride colanic acid. Mutations in this domain of the human N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein are the cause of paroxysmal nocturnal hemoglobinuria (PNH), an acquired hemolytic blood disorder characterised by venous thrombosis, erythrocyte hemolysis, infections and defective hematopoiesis. Short Name:  Glyco_trans_1

0 Child Features

0 Contains

1 Cross References


9 Found Ins

DB identifier Type Name
IPR012820 Family Sucrose synthase, plant/cyanobacteria
IPR011835 Family Bacterial/plant glycogen synthase
IPR012819 Family Sucrose phosphate synthase, plant
IPR014267 Family Glycosyltransferase Gtf1
IPR012822 Domain Sucrose-phosphate synthase, glycosyltransferase domain
IPR017521 Family Sugar transferase, PEP-CTERM, Stp1
IPR017522 Family Sugar transferase, PEP-CTERM, Stp2
IPR017814 Family Mycothiol biosynthesis protein, MshA
IPR011875 Family Glycogen synthase, corynebacterial

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3279 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
148419 D8RMM3 PAC:15407635 Selaginella moellendorffii 1104  
98243 PAC:15412108 Selaginella moellendorffii 438  
149847 D8RTS9 PAC:15413930 Selaginella moellendorffii 569  
103260 D8RVZ8 PAC:15407445 Selaginella moellendorffii 452  
79637 D8QWP9 PAC:15403561 Selaginella moellendorffii 497  
80274 D8QXT7 PAC:15403775 Selaginella moellendorffii 451  
80176 D8QWI4 PAC:15403060 Selaginella moellendorffii 548  
20205 PAC:15405129 Selaginella moellendorffii 1032  
81578 PAC:15409115 Selaginella moellendorffii 516  
110377 PAC:15406734 Selaginella moellendorffii 401  
419653 D8S9L6 PAC:15411274 Selaginella moellendorffii 233  
406541 D8R2Q4 PAC:15416800 Selaginella moellendorffii 430  
154776 D8SEU0 PAC:15405633 Selaginella moellendorffii 899  
155312 PAC:15405322 Selaginella moellendorffii 492  
77446 PAC:15418650 Selaginella moellendorffii 527  
91988 D8REA5 PAC:15419388 Selaginella moellendorffii 1030  
evm.TU.contig_29609.1 PAC:16429716 Carica papaya 851  
evm.TU.contig_36490.1 PAC:16430845 Carica papaya 381  
evm.model.supercontig_128.71 PAC:16407499 Carica papaya 584  
evm.model.supercontig_142.9 PAC:16408994 Carica papaya 1021  
evm.model.supercontig_163.3 PAC:16410311 Carica papaya 434  
evm.model.supercontig_17.97 PAC:16410824 Carica papaya 958  
evm.model.supercontig_178.35 PAC:16411166 Carica papaya 862  
evm.model.supercontig_18.204 PAC:16411354 Carica papaya 457  
evm.model.supercontig_217.19 PAC:16413804 Carica papaya 908  
evm.model.supercontig_253.2 PAC:16414959 Carica papaya 683  
evm.model.supercontig_3.93 PAC:16416881 Carica papaya 613  
evm.model.supercontig_305.3 PAC:16417091 Carica papaya 481  
evm.model.supercontig_37.97 PAC:16418774 Carica papaya 613  
evm.model.supercontig_46.57 PAC:16420524 Carica papaya 1052  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID