Protein Domain : IPR000597

Type:  Family Name:  Ribosomal protein L3
Description:  Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites [, ]. About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to - the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits. Many ribosomal proteins, particularly those of the large subunit, are composed of a globular, surfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilise its structure. Most of the proteins interact with multiple RNA elements, often from different domains. In the large subunit, about 1/3 of the 23S rRNA nucleotides are at least in van der Waal's contact with protein, and L22 interacts with all six domains of the 23S rRNA. Proteins S4 and S7, which initiate assembly of the 16S rRNA, are located at junctions of five and four RNA helices, respectively. In this way proteins serve to organise and stabilise the rRNA tertiary structure. While the crucial activities of decoding and peptide transfer are RNA based, proteins play an active role in functions that may have evolved to streamline the process of protein synthesis. In addition to their function in the ribosome, many ribosomal proteins have some function 'outside' the ribosome [, ].Ribosomal protein L3 is one of the proteins from the large ribosomal subunit. In Escherichia coli, L3 is known to bind to the 23S rRNA and may participate in the formation of the peptidyltransferase centre of the ribosome. Itbelongs to a family of ribosomal proteins which, on the basis of sequence similarities includes bacterial, red algal, cyanelle, mammalian, yeast and Arabidopsis thalianaL3 proteins; archaeal Haloarcula marismortuiHmaL3 (HL1), and yeast mitochondrial YmL9 [, , ]. Short Name:  Ribosomal_L3

2 Child Features

DB identifier Type Name
IPR019927 Family Ribosomal protein L3, bacterial/organelle-type
IPR019928 Family Ribosomal protein L3, archaeal

1 Contains

DB identifier Type Name
IPR019926 Conserved_site Ribosomal protein L3, conserved site

1 Cross References

Identifier
PF00297

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0003735 IPR000597
GO:0006412 IPR000597
GO:0005622 IPR000597
GO:0005840 IPR000597

4 Ontology Annotations

GO Term Gene Name
GO:0003735 IPR000597
GO:0006412 IPR000597
GO:0005622 IPR000597
GO:0005840 IPR000597

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
430901 D8TAW5 PAC:15401452 Selaginella moellendorffii 222  
270706 D8RB94 PAC:15422424 Selaginella moellendorffii 389  
145395 D8RAR7 PAC:15420703 Selaginella moellendorffii 255  
evm.model.supercontig_113.41 PAC:16406052 Carica papaya 160  
evm.model.supercontig_146.23 PAC:16409111 Carica papaya 318  
evm.model.supercontig_192.20 PAC:16412190 Carica papaya 364  
evm.model.supercontig_49.101 PAC:16421011 Carica papaya 389  
evm.model.supercontig_73.31 PAC:16425609 Carica papaya 222  
29765.m000743 B9SKD1 PAC:16808212 Ricinus communis 389  
29863.m001058 B9SE83 PAC:16811680 Ricinus communis 389  
29889.m003398 B9S007 PAC:16812344 Ricinus communis 311  
30148.m001406 B9SD98 PAC:16820552 Ricinus communis 285  
Cucsa.325800.1 A0A0A0KAJ9 PAC:16977989 Cucumis sativus 389  
Cucsa.325800.2 A0A0A0KAJ9 PAC:16977990 Cucumis sativus 389  
Cucsa.325800.3 PAC:16977991 Cucumis sativus 337  
Cucsa.325800.4 PAC:16977992 Cucumis sativus 306  
Cucsa.362620.1 PAC:16980955 Cucumis sativus 295  
Cucsa.076150.4 PAC:16955820 Cucumis sativus 336  
Cucsa.076150.1 A0A0A0KT85 PAC:16955817 Cucumis sativus 388  
Cucsa.076150.2 A0A0A0KT85 PAC:16955818 Cucumis sativus 388  
Cucsa.076150.3 A0A0A0KT85 PAC:16955819 Cucumis sativus 388  
Cucsa.252160.1 A0A0A0LAV0 PAC:16971910 Cucumis sativus 328  
orange1.1g016467m A0A067DM66 PAC:18113394 Citrus sinensis 389  
orange1.1g016469m A0A067DM66 PAC:18113395 Citrus sinensis 389  
orange1.1g022045m A0A067DZR1 PAC:18113396 Citrus sinensis 303  
orange1.1g038172m A0A067GVM7 PAC:18091957 Citrus sinensis 323  
orange1.1g023905m A0A067E6B0 PAC:18110898 Citrus sinensis 275  
AT3G17465.1 Q9LRN8 PAC:19660694 Arabidopsis thaliana 324  
AT1G43170.2 P17094 PAC:19657403 Arabidopsis thaliana 389  
AT1G43170.5 P17094 PAC:19657405 Arabidopsis thaliana 389  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11297922
            11290319
            11114498
            1597181
            1499563
            2406244