Protein Domain : IPR005708

Type:  Family Name:  Homogentisate 1,2-dioxygenase
Description:  Alkaptonuria (AKU), a rare hereditary disorder, was the first disease to be interpreted as an inborn error of metabolism. The deficiency causes homogentisic aciduria, ochronosis, and arthritis. AKU patients are deficient for homogentisate 1,2 dioxygenase (), the enzyme that mediates the conversion of homogentisate to maleylacetoacetate; a step in the catabolism of both tyrosine and phenylalanine. Homogentisate + O(2) = 4-maleylacetoacetate. Short Name:  Homogentis_dOase
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1 Child Features

DB identifier Type Name
IPR022950 Family Homogentisate 1,2-dioxygenase, bacterial

1 Contains

DB identifier Type Name
IPR011051 Domain RmlC-like cupin domain

3 Cross Referencess

Identifier
PTHR11056
PF04209
TIGR01015

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004411 IPR005708
GO:0006559 IPR005708
GO:0006570 IPR005708
GO:0055114 IPR005708

4 Ontology Annotations

GO Term Gene Name
GO:0004411 IPR005708
GO:0006559 IPR005708
GO:0006570 IPR005708
GO:0055114 IPR005708

0 Parent Features

489 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
267178 D8RBB3 PAC:15408984 Selaginella moellendorffii 445  
evm.model.supercontig_131.80 PAC:16408079 Carica papaya 462  
30209.m001534 B9RXB8 PAC:16824078 Ricinus communis 457  
Cucsa.273420.1 A0A0A0KYZ6 PAC:16973824 Cucumis sativus 471  
orange1.1g011768m A0A067ETR6 PAC:18120027 Citrus sinensis 478  
orange1.1g019943m A0A067ETI5 PAC:18120029 Citrus sinensis 333  
orange1.1g011934m A0A067F4S9 PAC:18120028 Citrus sinensis 474  
AT5G54080.2 Q9ZRA2 PAC:19667594 Arabidopsis thaliana 461  
AT5G54080.1 Q9ZRA2 PAC:19667593 Arabidopsis thaliana 461  
Thhalv10013691m PAC:20205837 Eutrema salsugineum 409  
Ciclev10008509m V4UR80 PAC:20794998 Citrus clementina 401  
Lus10027840 PAC:23156917 Linum usitatissimum 629  
Lus10028135 PAC:23166563 Linum usitatissimum 444  
Lus10042839 PAC:23181671 Linum usitatissimum 461  
Potri.001G374100.1 PAC:27042116 Populus trichocarpa 473  
Potri.001G374100.5 PAC:27042119 Populus trichocarpa 379  
Potri.001G374100.4 PAC:27042120 Populus trichocarpa 323  
Potri.001G374100.2 B9GGF0 PAC:27042117 Populus trichocarpa 464  
Potri.001G374100.3 PAC:27042118 Populus trichocarpa 446  
Gorai.002G065000.3 A0A0D2Q1M6 PAC:26796596 Gossypium raimondii 457  
Gorai.002G065000.4 A0A0D2Q1M1 PAC:26796597 Gossypium raimondii 419  
Gorai.002G065000.5 A0A0D2M7H0 PAC:26796598 Gossypium raimondii 394  
Gorai.002G065000.8 A0A0D2R1M3 PAC:26796599 Gossypium raimondii 340  
Gorai.002G065000.6 A0A0D2Q8M2 PAC:26796600 Gossypium raimondii 326  
Gorai.002G065000.7 A0A0D2NIZ0 PAC:26796601 Gossypium raimondii 313  
Gorai.002G065000.2 A0A0D2NIY8 PAC:26796594 Gossypium raimondii 469  
Gorai.002G065000.1 A0A0D2NIY8 PAC:26796595 Gossypium raimondii 469  
52808 I0Z3N2 PAC:27389788 Coccomyxa subellipsoidea C-169 501  
161798 PAC:27339527 Micromonas pusilla CCMP1545 649  
Thecc1EG031685t1 A0A061F763 PAC:27444538 Theobroma cacao 451  

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