3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0000107 | IPR004651 |
| GO:0000105 | IPR004651 |
| GO:0005737 | IPR004651 |
| Type: | Family | Name: | Histidine biosynthesis, HisF |
| Description: | Histidine is formed by several complex and distinct biochemical reactions catalysed by eight enzymes. Proteins involved in steps 4 and 6 of the histidine biosynthesis pathway are contained in one family. These enzymes are calledHis6 and His7 in eukaryotes and HisA and HisF in prokaryotes. HisA is a phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (), involved in the fourth step of histidine biosynthesis. The bacterial HisF protein is a cyclase which catalyzes the cyclization reaction that produces D-erythro-imidazole glycerol phosphate duringthe sixth step of histidine biosynthesis. The yeast His7 protein is a bifunctional protein which catalyzes an amido-transferase reaction that generates imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide. The latter is theribonucleotide used for purine biosynthesis. The enzyme also catalyzes the cyclization reaction that produces D-erythro-imidazole glycerol phosphate, and is involved in the fifth and sixth steps in histidine biosynthesis.This family describes the histidine biosynthesis protein, HisF. | Short Name: | HisF |
| GO Term | Gene Name |
|---|---|
| GO:0000107 | IPR004651 |
| GO:0000105 | IPR004651 |
| GO:0005737 | IPR004651 |
