Type: | Domain | Name: | Thiamin pyrophosphokinase, vitamin B1-binding domain |
Description: | Thiamin pyrophosphokinase (TPK, ) catalyzes the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the coenzyme thiamin pyrophosphate (TPP). Thus, TPK is important for the formation of a coenzyme required for central metabolic functions. The structure of thiamin pyrophosphokinase suggest that the enzyme may operate by a mechanism of pyrophosphoryl transfer similar to those described for pyrophosphokinases functioning in nucleotide biosynthesis []. | Short Name: | Thiamin_PyroPKinase_B1-bd |