Protein Domain : IPR010034

Type:  Family Name:  Molybdopterin converting factor, subunit 1
Description:  This entry describes bacterial and eukaryotic MoaD.Molybdenum cofactor biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, and eukaryotes, including humans. Genetic deficiencies of enzymes involved in cofactor biosynthesis in humans lead to a severe and usually fatal disease. The molybdenum cofactor contains a tricyclic pyranopterin, termedmolybdopterin, that bears the cis-dithiolene group responsible for molybdenum ligation. The dithiolene group of molybdopterin is generated by molybdopterin synthase, which consists of a large (MoaE) and small (MoaD) subunit. The crystal structure of molybdopterin synthase revealed a heterotetrameric enzyme in whichthe C terminus of each MoaD subunit is deeply inserted into a MoaE subunit to form the active site. In the activated form of the enzyme, the MoaD C terminus is present as a thiocarboxylate. The structure of molybdopterin synthase revealed a binding pocket for the terminal phosphate of molybdopterin, the product of the enzyme, and suggested a binding site for the pterin moiety present in precursor Z and molybdopterin. Finally, the crystal structure of the MoaE homodimer provides insights into the conformational changes accompanying binding of the MoaD subunit []. Short Name:  Mopterin_su_1
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0 Child Features

1 Contains

DB identifier Type Name
IPR016155 Domain Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp

1 Cross References

Identifier
TIGR01682

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0006777 IPR010034

1 Ontology Annotations

GO Term Gene Name
GO:0006777 IPR010034

1 Parent Features

DB identifier Type Name
IPR003749 Family ThiamineS/Molybdopterin converting factor subunit 1

395 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
138571 D8TFN3 PAC:15401417 Selaginella moellendorffii 91  
89945 D8RBE3 PAC:15413247 Selaginella moellendorffii 91  
evm.model.supercontig_21.88 PAC:16413603 Carica papaya 119  
orange1.1g034042m A0A067DVK0 PAC:18129874 Citrus sinensis 105  
orange1.1g034057m A0A067DVK0 PAC:18129872 Citrus sinensis 105  
orange1.1g034054m A0A067DVK0 PAC:18129873 Citrus sinensis 105  
AT4G10100.3 Q9S7A3 PAC:19646523 Arabidopsis thaliana 96  
AT4G10100.1 Q9S7A3 PAC:19646521 Arabidopsis thaliana 96  
AT4G10100.2 Q9S7A3 PAC:19646522 Arabidopsis thaliana 96  
Thhalv10029346m V4KKZ8 PAC:20197989 Eutrema salsugineum 150  
Lus10030343 PAC:23153190 Linum usitatissimum 109  
Potri.T076900.1 PAC:26993210 Populus trichocarpa 133  
Potri.019G070800.1 A0A2K1WQV6 PAC:27025576 Populus trichocarpa 101  
Potri.019G070800.2 A0A2K1WQV6 PAC:27025577 Populus trichocarpa 101  
Gorai.010G205800.1 A0A0D2RB39 PAC:26760219 Gossypium raimondii 101  
Gorai.010G205800.2 A0A0D2RB39 PAC:26760218 Gossypium raimondii 101  
12278 I0Z8E1 PAC:27393579 Coccomyxa subellipsoidea C-169 83  
52674 C1N4T5 PAC:27339723 Micromonas pusilla CCMP1545 84  
64811 C1EJ53 PAC:27397009 Micromonas sp RCC299 84  
Thecc1EG036308t1 A0A061FJ92 PAC:27459287 Theobroma cacao 263  
Thecc1EG036308t2 A0A061FKE7 PAC:27459288 Theobroma cacao 103  
Glyma.06G321300.3.p C6T427 PAC:30549213 Glycine max 102  
Glyma.06G321300.4.p C6T427 PAC:30549211 Glycine max 102  
Glyma.06G321300.1.p C6T427 PAC:30549212 Glycine max 102  
Glyma.06G321300.2.p C6T427 PAC:30549210 Glycine max 102  
Brara.I02532.1.p A0A397Y5F5 PAC:30640761 Brassica rapa FPsc 103  
Bostr.25463s0309.1.p PAC:30679941 Boechera stricta 96  
Cre08.g382545.t1.1 A8JJB2 PAC:30773615 Chlamydomonas reinhardtii 83  
Medtr3g008540.1 G7IYH1 PAC:31055027 Medicago truncatula 103  
Medtr3g008540.3 G7IYH1 PAC:31055028 Medicago truncatula 103  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12571227