Protein Domain : IPR006223

Type:  Family Name:  Glycine cleavage system T protein
Description:  The glycine cleavage system (GCS) is a multienzyme system composed of proteins P, H, T, and L, that catalyses the reversible oxidation of glycine. The T protein is an aminomethyl transferase that catalyses the following reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3+ dihydrolipoylprotein The glycine cleavage system is found in bacteria and the mitochondria of eukaryotes. Mutations in the human T-protein gene are known to cause nonketotic hyperglycinemia []. Short Name:  GCS_T
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1 Child Features

DB identifier Type Name
IPR022903 Family Glycine cleavage system T protein, bacteria

2 Contains

DB identifier Type Name
IPR013977 Domain Glycine cleavage T-protein, C-terminal barrel domain
IPR006222 Domain Glycine cleavage T-protein-like, N-terminal

2 Cross Referencess

Identifier
PTHR13847:SF5
TIGR00528

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0004047 IPR006223
GO:0006546 IPR006223

2 Ontology Annotations

GO Term Gene Name
GO:0004047 IPR006223
GO:0006546 IPR006223

1 Parent Features

DB identifier Type Name
IPR028896 Family Aminomethyltransferase/Dimethylsulfonioproprionate demethylase DmdA

517 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
272095 D8T2P9 PAC:15423109 Selaginella moellendorffii 409  
evm.model.supercontig_152.29 PAC:16409612 Carica papaya 196  
29842.m003567 B9RXI7 PAC:16810700 Ricinus communis 407  
Cucsa.085690.1 PAC:16956685 Cucumis sativus 407  
orange1.1g015308m A0A067GFA3 PAC:18112983 Citrus sinensis 409  
orange1.1g015297m A0A067GFA3 PAC:18112984 Citrus sinensis 409  
orange1.1g015320m A0A067GFA3 PAC:18112985 Citrus sinensis 409  
orange1.1g015314m A0A067GFA3 PAC:18112986 Citrus sinensis 409  
AT1G11860.3 O65396 PAC:19651801 Arabidopsis thaliana 408  
AT1G11860.2 O65396 PAC:19651800 Arabidopsis thaliana 408  
AT1G11860.1 O65396 PAC:19651799 Arabidopsis thaliana 408  
Thhalv10007781m V4MUJ7 PAC:20188158 Eutrema salsugineum 408  
Thhalv10007782m V4MUJ7 PAC:20188160 Eutrema salsugineum 408  
Thhalv10007779m V4MUJ7 PAC:20188159 Eutrema salsugineum 408  
Ciclev10015433m V4W9M5 PAC:20818223 Citrus clementina 409  
Lus10001624 PAC:23145996 Linum usitatissimum 296  
Lus10001441 PAC:23170706 Linum usitatissimum 416  
Potri.004G009600.1 A0A2K2AN88 PAC:26991576 Populus trichocarpa 408  
Potri.011G006800.1 U7E312 PAC:27002062 Populus trichocarpa 408  
Potri.011G006800.3 U7E312 PAC:27002063 Populus trichocarpa 408  
Potri.011G006800.2 U7E312 PAC:27002064 Populus trichocarpa 408  
Gorai.009G179900.2 A0A0D2S3B3 PAC:26761804 Gossypium raimondii 407  
Gorai.009G179900.5 A0A0D2S3B3 PAC:26761805 Gossypium raimondii 407  
Gorai.009G179900.3 A0A0D2S3B3 PAC:26761806 Gossypium raimondii 407  
Gorai.009G179900.8 A0A0D2S3B3 PAC:26761810 Gossypium raimondii 407  
Gorai.009G179900.1 A0A0D2TLS4 PAC:26761803 Gossypium raimondii 409  
Gorai.009G179900.7 A0A0D2S3B3 PAC:26761809 Gossypium raimondii 407  
Gorai.009G179900.4 A0A0D2S3B3 PAC:26761807 Gossypium raimondii 407  
Gorai.009G179900.6 A0A0D2S3B3 PAC:26761808 Gossypium raimondii 407  
Gorai.010G181500.1 A0A0D2R9Q3 PAC:26760559 Gossypium raimondii 407  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            20375021