Protein Domain : IPR001193

Type:  Family Name:  Membrane-bound transcription factor site-2 protease
Description:  This entry represents the membrane-bound transcription factor site-2 protease (MBTPS2, also known as S2P)[]. MBTPS2 is a membrane-embedded zinc metalloprotease that activates signaling proteins involved in sterol control of transcription and ER stress response []. It cleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Its known substrates include sterol regulatory element-binding protein (SREBP) -1, SREBP-2 and forms of the transcriptional activator ATF6 [, ]. Mutations in the MBTPS2 gene cause IFAP syndrome with or without BRESHECK syndrome (IFAPS) and Keratosis follicularis spinulosa decalvans X-linked (KFSDX) [, ]. Short Name:  MBTPS2
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0 Child Features

1 Contains

DB identifier Type Name
IPR008915 Domain Peptidase M50

2 Cross Referencess

Identifier
PTHR13325
PR01000

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0004222 IPR001193
GO:0006508 IPR001193
GO:0016020 IPR001193

3 Ontology Annotations

GO Term Gene Name
GO:0004222 IPR001193
GO:0006508 IPR001193
GO:0016020 IPR001193

0 Parent Features

864 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
430732 D8TAC1 PAC:15422238 Selaginella moellendorffii 315  
447922 D8T3J6 PAC:15406806 Selaginella moellendorffii 189  
evm.model.supercontig_30.57 PAC:16417007 Carica papaya 604  
27837.m000155 B9T384 PAC:16799304 Ricinus communis 537  
Cucsa.202470.1 A0A0A0KQ25 PAC:16968981 Cucumis sativus 541  
orange1.1g042181m PAC:18138908 Citrus sinensis 417  
AT4G20310.1 PAC:19647951 Arabidopsis thaliana 393  
AT4G20310.3 F4JUU7 PAC:19647952 Arabidopsis thaliana 374  
AT4G20310.2 PAC:19647950 Arabidopsis thaliana 488  
Thhalv10024898m V4MIW7 PAC:20194672 Eutrema salsugineum 527  
Ciclev10015668m V4UCB0 PAC:20817816 Citrus clementina 371  
Lus10001219 PAC:23148484 Linum usitatissimum 547  
Lus10038402 PAC:23158440 Linum usitatissimum 474  
Potri.001G073200.1 PAC:27047970 Populus trichocarpa 244  
Potri.003G157800.2 A0A2K2B7V2 PAC:26998310 Populus trichocarpa 404  
Potri.003G157800.3 PAC:26998309 Populus trichocarpa 509  
Potri.003G157800.1 A0A2K2B7T3 PAC:26998308 Populus trichocarpa 539  
Gorai.013G126100.1 A0A0D2VEH4 PAC:26786917 Gossypium raimondii 528  
Gorai.013G126100.2 A0A0D2W5H1 PAC:26786918 Gossypium raimondii 509  
41457 I0Z0K0 PAC:27391388 Coccomyxa subellipsoidea C-169 502  
Thecc1EG026662t1 A0A061F386 PAC:27424957 Theobroma cacao 532  
Migut.G00899.1.p PAC:28942981 Mimulus guttatus 423  
Migut.G00899.2.p PAC:28942982 Mimulus guttatus 411  
Migut.K01517.2.p PAC:28937986 Mimulus guttatus 528  
Migut.K01517.1.p PAC:28937985 Mimulus guttatus 528  
Migut.M02039.1.p PAC:28949249 Mimulus guttatus 528  
Araha.8052s0004.1.p PAC:28851437 Arabidopsis halleri 374  
Cagra.4235s0007.1.p PAC:28898211 Capsella grandiflora 513  
Glyma.16G096000.1.p A0A368UGX6 PAC:30560528 Glycine max 539  
Brara.A01100.1.p A0A398AKR6 PAC:30638680 Brassica rapa FPsc 522  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9659902
            19361614
            20672378
            10419520