| Type: | Domain | Name: | Carboxypeptidase, regulatory domain |
| Description: | This domain identifies a number of eukaryotic carboxypeptidases, these include carboxypeptidase D, E (H), N, X, X2 and Z. These are metallopeptidases belong to MEROPS peptidase family M14 (clan MC), subfamily M14B.Carboxypeptidase D (CPD) is a new B-type metallocarboxypeptidase that is membrane bound and has an acidic pH optimum. A hydrophobic region at the N terminus represents the signal peptide, and one near the C terminus that probably represents the transmembrane anchor. A regulatory domain within the protein has been identified as a beta-sandwich, comprising 7 strands in 2 sheets in a greek-key topology. Some family members have an additional 1-2 strands to the common fold [].The bacterial and archaeal sequences having this signature are variously annotated, examples are:Hypothetical/conserved/membrane/cell surface protein N-acetylglucosamine deacetylaseSide tail fibre protein homologue from lambdoid prophage RacHypothetical tonB-linked outer membrane receptorOmpA-related proteinPutative outer membrane protein, probably involved in nutrient bindingTonB-dependent receptorThis entry also includes polysaccharide lyase 4 family members, including rhamnogalacturonate lyase A and B. | Short Name: | CarboxyPept_regulatory_dom |
