Type: | Domain | Name: | JmjN domain |
Description: | The JmjN and JmjC domains are two non-adjacent domains which have been identified in the jumonji family of transcription factors. Although it wasoriginally suggested that the JmjN and JmjC domains always co-occur and might form a single functional unit within the folded protein, the JmjC domain waslatter found without the JmjN domain in organisms from bacteria to human [, ].JmJC domains are predicted to be metalloenzymes that adopt the cupin fold, and are candidates for enzymes that regulate chromatin remodelling. The cupin fold is a flattened beta-barrel structure containingtwo sheets of five antiparallel beta strands that form the walls of a zinc- binding cleft. JmjC domains were identified in numerous eukaryotic proteinscontaining domains typical of transcription factors, such as PHD, C2H2, ARID/BRIGHT and zinc fingers [, ]. TheJmjC has been shown to function in a histone demethylation mechanism that is conserved from yeast to human []. | Short Name: | JmjN |