Protein Domain : IPR001507

Type:  Domain Name:  Zona pellucida domain
Description:  The zona pellucida (ZP) domain is a protein polymerisation module of ~260 amino acid module, which is found at the C terminus of many secretedeukaryotic glycoproteins that play fundamental roles in development, hearing, immunity, and cancer [, , , ].Proteins containing a ZP domain include: Sperm receptor proteins ZP2 and ZP3. Along with protein ZP1, proteins ZP2 and ZP3 are responsible for sperm-adhesion to the zona pellucida. ZP3 firstbinds to specific sperm proteins, thus mediating sperm contacts with the oocyte. ZP2 acts as a second sperm receptor reinforcing the interactions.ZP1 cross-links the polymers formed by ZP2 and ZP3.Zona pellucida sperm-binding protein B (ZP-B) (also known as ZP-X in rabbit and ZP-3 alpha in pig).Glycoprotein GP2, the major component of pancreatic secretory granule membranes.TGF-beta receptor type III (also known as betaglycan). This protein is a proteoglycan that binds to TGF-beta and could be involved in capturing andretaining TGF-beta for presentation to the signalling receptors.Uromodulin (also known as Tamm-Horsfall urinary glycoprotein). The function of this protein, which is the most abundant in human urine, is not yetclear.Chicken beta-tectorin, a major glycoprotein of avian tectorial membrane.Most ZP domain proteins are synthesized as precursors with carboxy-terminal transmembrane domains or glycosyl phosphatidylinositol (GPI) anchors [].The ZP domain contains eight strictly conserved cysteines, which form disulphide bridges. The disulphide bonds within the ZP domains are divided intotwo groups, suggesting that the ZP domain consists of two subdomains. In addition to the conserved cysteines, only a few aromatic or hydrophobic aminoacids are absolutely invariant, probably as a result of structural rather than functional constraints [, , ]. Short Name:  ZP_dom
Paste the following link

0 Child Features

1 Contains

DB identifier Type Name
IPR017977 Conserved_site Zona pellucida domain, conserved site

4 Cross Referencess

Identifier
PF00100
PR00023
PS51034
SM00241

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

5 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Aqcoe3G280900.1.p A0A2G5F1I3 PAC:33095032 Aquilegia coerulea 1059  
Brdisv1Bd21-3_r1008616m.p PAC:35570772 Brachypodium distachyon Bd21-3 141  
Potri.019G120800.2.p PAC:42773570 Populus trichocarpa 233  
VIT_207s0095g00620.1 PAC:38058204 Vitis vinifera 80  
VIT_207s0095g00620.1 PAC:38058204 Vitis vinifera 80  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1313375
            12021773
            12878193
            15079052