Protein Domain : IPR000857

Type:  Domain Name:  MyTH4 domain
Description:  The microtubule-based kinesin motors and actin-based myosin motors generate movements required for intracellular trafficking, cell division, and muscle contraction. In general, these proteins consist of a motor domain that generates movement and a tail region that varies widely from class to class and is thought to mediate many of the regulatory or cargo binding functions specific to each class of motor []. The Myosin Tail Homology 4 (MyTH4) domain has been identified as a conserved domain in the tail domains of several different unconventional myosins [] and a plant kinesin-like protein [], but has more recently been found in several non-motor proteins []. Although the function is not yet fully understood, there is an evidence that the MyTH4 domain of Myosin-X (Myo10) binds to microtubules and thus could provide a link between an actin-based motor protein and the microtubule cytoskeleton [].The MyTH4 domain is found in one or two copies associated with other domains, such as myosin head, kinesin motor, FERM, PH, SH3 and IQ. The domain is predicted to be largely alpha-helical, interrupted by three orfour turns. The MyTH4 domain contains four highly conserved regions designated MGD (consensus sequence L(K/R)(F/Y)MGDhP, LRDE (consensus LRDEhYCQhhKQHxxxN),RGW (consensus RGWxLh), and ELEA (RxxPPSxhELEA), where h indicates a hydrophobic residue and x is any residue []. Short Name:  MyTH4_dom

0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF00784
PS51016
SM00139

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0005856 IPR000857

1 Ontology Annotations

GO Term Gene Name
GO:0005856 IPR000857

0 Parent Features

726 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
448937 PAC:15409828 Selaginella moellendorffii 1285  
414494 D8RSY6 PAC:15417510 Selaginella moellendorffii 824  
409859 PAC:15405509 Selaginella moellendorffii 1224  
evm.model.supercontig_17.14 PAC:16410633 Carica papaya 1286  
29682.m000589 B9SRC0 PAC:16805681 Ricinus communis 1261  
Cucsa.323300.1 PAC:16977928 Cucumis sativus 1128  
orange1.1g000820m A0A067FW81 PAC:18098834 Citrus sinensis 1268  
orange1.1g000817m A0A067FW81 PAC:18098833 Citrus sinensis 1268  
AT5G65930.1 Q9FHN8 PAC:19669416 Arabidopsis thaliana 1259  
AT5G65930.3 F4JXM5 PAC:19669414 Arabidopsis thaliana 1266  
AT5G65930.2 Q9FHN8 PAC:19669415 Arabidopsis thaliana 1260  
Thhalv10003532m V4JZT5 PAC:20199786 Eutrema salsugineum 1229  
Thhalv10003527m V4MIA8 PAC:20199785 Eutrema salsugineum 1262  
Ciclev10024719m V4RUS0 PAC:20799677 Citrus clementina 1363  
Lus10006064 PAC:23147739 Linum usitatissimum 1491  
Lus10009426 PAC:23149720 Linum usitatissimum 1238  
Potri.011G146700.1 PAC:27001201 Populus trichocarpa 1119  
Potri.011G146700.2 PAC:27001202 Populus trichocarpa 1119  
Potri.001G455300.2 PAC:27042655 Populus trichocarpa 1181  
Potri.001G455300.3 A0A2K2CDP4 PAC:27042654 Populus trichocarpa 1209  
Potri.001G455300.1 PAC:27042653 Populus trichocarpa 1220  
Gorai.003G001000.4 A0A0D2QDH2 PAC:26800145 Gossypium raimondii 1242  
Gorai.003G001000.2 A0A0D2QKP2 PAC:26800143 Gossypium raimondii 1268  
Gorai.003G001000.3 A0A0D2QKP2 PAC:26800144 Gossypium raimondii 1268  
Gorai.003G001000.1 A0A0D2QKP2 PAC:26800142 Gossypium raimondii 1268  
Gorai.003G001000.6 A0A0D2MHA8 PAC:26800147 Gossypium raimondii 1115  
Gorai.003G001000.5 A0A0D2RE54 PAC:26800146 Gossypium raimondii 1209  
52195 I0ZA65 PAC:27389341 Coccomyxa subellipsoidea C-169 1280  
45791 C1N0A3 PAC:27340150 Micromonas pusilla CCMP1545 1084  
62851 C1FJV4 PAC:27399599 Micromonas sp RCC299 1242  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11212352
            11401444
            1074599
            12062040
            15372037