3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0006281 | IPR027786 |
| GO:0005634 | IPR027786 |
| GO:0030915 | IPR027786 |
| Type: | Family | Name: | Nse4/EID family |
| Description: | Proteins in the NSE4/EID (Non-structural maintenance of chromosomes element 4/EP300-interacting inhibitor of differentiation 3) family are components of the Smc5/6 complex that is involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components [, , ]. In human, it acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. It may function as a coinhibitor of other CREBBP/EP300-dependent transcription factors []. Interestingly, there is a single NSE4 gene in most eukaryotes up to non-placental mammals while there are several NSE4/EID copies in placental mammals []. In humans, there are two NSE4 proteins, NSE4a and NSE4b/EID3. They contain both N and C-terminal kleisin domains. Their N-terminal domain binds to the Nse3 (another SMC5-6 complex subunit) pocket []. | Short Name: | Nse4/EID |
| GO Term | Gene Name |
|---|---|
| GO:0006281 | IPR027786 |
| GO:0005634 | IPR027786 |
| GO:0030915 | IPR027786 |
