1 Contains
| DB identifier | Type | Name |
|---|---|---|
| IPR020555 | Conserved_site | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, conserved site |
| Type: | Domain | Name: | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase |
| Description: | IspF is a MECDP (2-C-methyl-D-erythritol 2,4-cyclodiphosphate) synthetase, also known as YgbB. It is an enzyme in the non-mevalonate pathway of isoprenoid synthesis. Isoprenoids are essential in all organisms, and can also be synthesized through the mevalonate pathway. The non-mevolante route is used by many bacteria and human pathogens, including Mycobacterium tuberculosisand Plasmodium falciparum. This route appears to involve seven enzymes. MECDP synthetase catalyses the intramolecular attack by a phosphate group on a diphosphate, with cytidine monophosphate (CMP) acting as the leaving group to give the cyclic diphosphate product MEDCP. The enzyme is a trimer with three active sites shared between adjacent copies of the protein. The enzyme also has two metal binding sites, the metals playing key roles in catalysis[].A number of proteins from eukaryotes and prokaryotes are bifunctional proteins with an N-terminal IspD domain and a C-terminal IspF domain []. | Short Name: | MECDP_synthase |
| DB identifier | Type | Name |
|---|---|---|
| IPR020555 | Conserved_site | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, conserved site |
