| Type: | Family | Name: | Mitochondrial ubiquitin ligase activator of NFKB 1 |
| Description: | Mitochondrial ubiquitin ligase activator of NFKB 1 (MULAN, also known as GIDE) exhibits weak E3 ubiquitin-protein ligase activity, but preferentially acts as a SUMO E3 ligase at physiological concentrations []. It plays a role in the control of mitochondrial morphology, promotes mitochondrial fragmentation and influences mitochondrial localisation []. When over-expressed in human cells, it activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis []. | Short Name: | MULAN |
