Protein Domain : IPR001368

Type:  Domain Name:  TNFR/NGFR cysteine-rich region
Description:  A number of proteins, some of which are known to be receptors for growth factors, have been found to contain a cysteine-rich domain of about 110 to160 amino acids in their N-terminal part, that can be subdivided into four (or in some cases, three) modules of about 40 residues containing 6 conservedcysteines. Some of the proteins containing this domain are listed below [, , ]:Tumor Necrosis Factor type I and type II receptors (TNFR). Both receptors bind TNF-alpha and TNF-beta, but are only similar in the cysteine-richregionShope fibroma virus soluble TNF receptor (protein T2)Lymphotoxin alpha/beta receptorLow-affinity nerve growth factor receptor (LA-NGFR) (p75)CD40 (Bp50), the receptor for the CD40L (or TRAP) cytokineCD27, the receptor for the CD27L cytokineCD30, the receptor for the CD30L cytokineT-cell protein 4-1BB, the receptor for the 4-1BBL putative cytokine FAS antigen (or APO-1), the receptor for FASL, a protein involved in apoptosis (programmed cell death)T-cell antigen OX40, the receptor for the OX40L cytokineWsl-1, a receptor (for a yet undefined ligand) that mediates apoptosisVaccinia virus protein A53 (SalF19R)It has been shown [] that the six cysteines all involved in intrachaindisulphide bonds. A schematic representation of the structure of the 40 residue module of these receptors is shown below:+-------------+ +--------------+ | | | |xCxxxxxxxxxxxxxCxCxxCxxxxxxxxxCxxxxCxx | |+------------+ 'C': conserved cysteine involved in a disulphide bond. Short Name:  TNFR/NGFR_Cys_rich_reg
Paste the following link

0 Child Features

0 Contains

4 Cross Referencess

Identifier
PF00020
PS00652
PS50050
SM00208

22 Found Ins

DB identifier Type Name
IPR017371 Family Tumour necrosis factor receptor 11B
IPR022329 Family Tumour necrosis factor receptor 25
IPR022330 Family Tumour necrosis factor receptor 21
IPR022318 Family Tumour necrosis factor receptor 18
IPR022319 Family Tumour necrosis factor receptor 27
IPR022342 Family Tumour necrosis factor receptor 19
IPR022332 Family Tumour necrosis factor receptor 14
IPR022333 Family Tumour necrosis factor receptor 19-like
IPR022323 Family Tumour necrosis factor receptor 11
IPR022361 Family Tumour necrosis factor receptor 11A
IPR022325 Family Tumour necrosis factor receptor 16
IPR022328 Family Tumour necrosis factor receptor 7
IPR020411 Family Tumour necrosis factor receptor 1B
IPR020413 Family Tumour necrosis factor receptor 9
IPR020416 Family Tumour necrosis factor receptor 8
IPR020419 Family Tumour necrosis factor receptor 1A
IPR020445 Family Tumour necrosis factor receptor 4
IPR020435 Family Tumour necrosis factor receptor 5
IPR020465 Family Tumour necrosis factor receptor 10
IPR017349 Family Tumour necrosis factor receptor 3
IPR008063 Family Fas receptor
IPR011172 Family Poxvirus, TNF-alpha receptor-II

1 GO Annotation

GO Term Gene Name
GO:0005515 IPR001368

1 Ontology Annotations

GO Term Gene Name
GO:0005515 IPR001368

0 Parent Features

553 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
413732 D8RQ17 PAC:15416716 Selaginella moellendorffii 465  
413726 D8RQ11 PAC:15416692 Selaginella moellendorffii 1033  
132932 D8T625 PAC:15409206 Selaginella moellendorffii 727  
evm.model.supercontig_102.4 PAC:16404859 Carica papaya 777  
evm.model.supercontig_53.67 PAC:16422293 Carica papaya 691  
evm.model.supercontig_9.282 PAC:16428182 Carica papaya 908  
29707.m000135 B9T5C6 PAC:16806371 Ricinus communis 920  
30078.m002339 B9S0M2 PAC:16817450 Ricinus communis 765  
28327.m000352 B9SU97 PAC:16800636 Ricinus communis 758  
Cucsa.094720.1 A0A0A0KU81 PAC:16957778 Cucumis sativus 921  
Cucsa.124310.1 A0A0A0KF28 PAC:16961686 Cucumis sativus 770  
orange1.1g040687m A0A067DG42 PAC:18120508 Citrus sinensis 740  
orange1.1g002512m A0A067E8W5 PAC:18128232 Citrus sinensis 914  
AT3G09780.1 Q9S7D9 PAC:19663078 Arabidopsis thaliana 775  
AT3G59420.1 Q9LX29 PAC:19662180 Arabidopsis thaliana 895  
Thhalv10020117m V4M2N1 PAC:20183617 Eutrema salsugineum 772  
Thhalv10005780m V4LNU6 PAC:20190202 Eutrema salsugineum 895  
Ciclev10011116m V4S3S2 PAC:20798653 Citrus clementina 776  
Ciclev10018759m V4VT12 PAC:20810776 Citrus clementina 914  
Lus10015956 PAC:23169799 Linum usitatissimum 888  
Potri.016G089200.1 B9IFM6 PAC:27013908 Populus trichocarpa 765  
Potri.017G029900.1 A0A2K1X2G8 PAC:26985220 Populus trichocarpa 922  
Potri.007G128400.1 B9HH53 PAC:27014647 Populus trichocarpa 906  
Potri.010G221200.1 A0A2K1YYE8 PAC:26981083 Populus trichocarpa 761  
Gorai.009G314400.1 A0A0D2TV48 PAC:26769503 Gossypium raimondii 769  
Gorai.006G167000.1 A0A0D2RXL8 PAC:26830782 Gossypium raimondii 709  
Gorai.011G142500.2 A0A0D2UT17 PAC:26810254 Gossypium raimondii 729  
Gorai.011G142500.1 A0A0D2VM72 PAC:26810253 Gossypium raimondii 910  
71069 C1N4C1 PAC:27339826 Micromonas pusilla CCMP1545 3898  
61687 C1FHY3 PAC:27397583 Micromonas sp RCC299 3770  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8387891
            15335933
            2174582
            15335677