Protein Domain : IPR000223

Type:  Family Name:  Peptidase S26A, signal peptidase I
Description:  This group of serine peptidases belong to MEROPS peptidase family S26 (signal peptidase I family, clan SF), subfamily S26A.At least 3 eubacterial leader peptidases are known: murein prelipoprotein peptidase, which cleaves the leader peptide from a component of thebacterial outer membrane; type IV prepilin leader peptidase; and the serine-dependent leader peptidase 1, which has the more general role of cleaving the leader peptide from a variety of secreted proteins and proteins directedto the periplasm and periplasmic membrane []. Leader peptidase 1 is similar to the eukaryotic signal peptidase, although the bacterial protein is monomeric, while the eukaryotic protein is multimeric [].Mitochondria contain a similar two-subunit serine protease that removes leader peptides from nuclear- and mitochondrial-encoded proteins, whichlocalise in the inner mitochondrial space []. The catalytic residues of a number of these peptides have been identified as a serine/lysine dyad []. Short Name:  Pept_S26A_signal_pept_1
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1 Child Features

DB identifier Type Name
IPR026730 Family Mitochondrial inner membrane protease subunit 1

6 Contains

DB identifier Type Name
IPR019533 Domain Peptidase S26
IPR019759 Domain Peptidase S24/S26A/S26B
IPR019766 Domain Peptidase S26A, all-beta subdomain
IPR019756 Active_site Peptidase S26A, signal peptidase I, serine active site
IPR019757 Active_site Peptidase S26A, signal peptidase I, lysine active site
IPR019758 Conserved_site Peptidase S26A, signal peptidase I, conserved site

3 Cross Referencess

Identifier
PTHR12383
PR00727
TIGR02227

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0008236 IPR000223
GO:0006508 IPR000223
GO:0016020 IPR000223

3 Ontology Annotations

GO Term Gene Name
GO:0008236 IPR000223
GO:0006508 IPR000223
GO:0016020 IPR000223

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
58024 D8SIT2 PAC:15403928 Selaginella moellendorffii 173  
121429 D8SNY0 PAC:15417570 Selaginella moellendorffii 186  
85448 D8R5M5 PAC:15419978 Selaginella moellendorffii 131  
86052 D8R4V8 PAC:15419869 Selaginella moellendorffii 143  
18112 D8SWY5 PAC:15420636 Selaginella moellendorffii 133  
91609 D8RE78 PAC:15416952 Selaginella moellendorffii 169  
272208 D8T794 PAC:15402204 Selaginella moellendorffii 198  
47339 D8T648 PAC:15418591 Selaginella moellendorffii 202  
evm.model.supercontig_1.337 PAC:16404274 Carica papaya 162  
evm.model.supercontig_163.21 PAC:16410302 Carica papaya 154  
evm.model.supercontig_23.94 PAC:16414309 Carica papaya 328  
evm.model.supercontig_357.9 PAC:16418268 Carica papaya 366  
evm.model.supercontig_43.112 PAC:16419921 Carica papaya 84  
evm.model.supercontig_50.14 PAC:16421599 Carica papaya 205  
evm.model.supercontig_64.137 PAC:16424210 Carica papaya 123  
29693.m002044 B9S148 PAC:16806014 Ricinus communis 176  
29701.m000603 B9SQ38 PAC:16806135 Ricinus communis 170  
29912.m005509 B9RKP7 PAC:16813384 Ricinus communis 313  
30026.m001516 B9S8I3 PAC:16815901 Ricinus communis 158  
30170.m013939 B9R7J2 PAC:16821783 Ricinus communis 831  
29648.m001995 B9S2V6 PAC:16804837 Ricinus communis 171  
27645.m000038 B9TBH1 PAC:16798889 Ricinus communis 225  
29611.m000227 B9T1B1 PAC:16803671 Ricinus communis 137  
Cucsa.388190.1 A0A0A0KA69 PAC:16982814 Cucumis sativus 205  
Cucsa.388190.2 PAC:16982815 Cucumis sativus 202  
Cucsa.047590.1 PAC:16953701 Cucumis sativus 175  
Cucsa.047590.2 PAC:16953702 Cucumis sativus 175  
Cucsa.047590.3 PAC:16953703 Cucumis sativus 175  
Cucsa.047590.4 PAC:16953704 Cucumis sativus 127  
Cucsa.123370.1 A0A0A0L290 PAC:16961588 Cucumis sativus 369  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7845208