| Type: | Domain | Name: | Peptidase S24/S26, beta-ribbon domain |
| Description: | This entry represents a stuctural domain superfamily found in serine peptidases belonging to MEROPS peptidase families: S24 (LexA family, clan SF); S26A (signal peptidase I), S26B (signalase) and S26C TraF peptidase. This domain has a complex fold made of several coiled beta-sheets, which contains an SH3-like barrel structure.The S26 family includes Escherichia colisignal peptidase, SPase, which is a membrane-bound endopeptidase with two N-terminal transmembrane segments and a C-terminal catalytic region []. SPase functions to release proteins that have been translocated into the inner membrane from the cell interior, by cleaving off their signal peptides. In SPase proteins, this domain is disrupted by the insertion of an additional all-beta subdomain. Note: Only the beta-ribbon domain is represented by this signature; the insert all-beta subdomain is represented by .The S24 family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins []. LexA, the repressor of genes in the cellular SOS response to DNA damage []. MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage []. UmuD is self-processed by its own serine protease activity during the SOS response.RulA, a component of the rulAB locus that confers resistance to UV. | Short Name: | Peptidase_S24/S26_b-rbn |
