1 Contains
DB identifier | Type | Name |
---|---|---|
IPR018089 | Active_site | Orotidine 5'-phosphate decarboxylase, active site |
Type: | Domain | Name: | Orotidine 5'-phosphate decarboxylase domain |
Description: | Orotidine 5'-phosphate decarboxylase (OMPdecase) [, ] catalyses the last step in the de novobiosynthesis of pyrimidines, the decarboxylation of OMP into UMP. In higher eukaryotes OMPdecase is part, with orotate phosphoribosyltransferase, of a bifunctional enzyme, while the prokaryotic and fungal OMPdecases are monofunctional protein.Some parts of the sequence of OMPdecase are well conserved across species. The best conserved region is located in the N-terminal half of OMPdecases and is centred around a lysine residue which is essential for the catalytic function of the enzyme.This entry also includes enzymes such as 3-hexulose-6-phosphate synthase and 3-keto-L-gulonate-6-phosphate decarboxylase . | Short Name: | OMPdeCOase_dom |
DB identifier | Type | Name |
---|---|---|
IPR018089 | Active_site | Orotidine 5'-phosphate decarboxylase, active site |