| Type: | Domain | Name: | Association with the SNF1 complex (ASC) domain |
| Description: | Association with the SNF1 complex (ASC) domain is found in the Sip1/Sip2/Gal83/AMPKbeta subunits of the SNF1/AMP-activated protein kinase (AMPK) complex []. The SNF1/AMPK are heterotrimeric enzymes composed of a catalytic alpha-subunit, a regulatory gamma-subunit and a regulatory/targeting beta-subunit []. Saccharomyces cerevisiae encodes three beta-subunit genes, Sip1, Sip2 and Gal83 [, ]. The beta-subunits function as target selective adaptors that recruit the catalytic kinase and regulator Snf4/gamma-subunits. The ASC domain is required for interaction with Snf4 [, ].The SNF1 kinase complex is required for transcriptional, metabolic, and developmental adaptations in response to glucose limitation [, ]. As glucose levels decrease, Snf1 is activated and promotes the use of alternative carbon sources. | Short Name: | ASC_dom |
