| Type: | Family | Name: | Isocitrate dehydrogenase NAD-dependent |
| Description: | Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologues. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and belog to this group. The NADP-dependent IDH of Thermus thermophilusstrain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus. | Short Name: | Isocitrate_DH_NAD |
| DB identifier | Type | Name |
|---|---|---|
| IPR019818 | Conserved_site | Isocitrate/isopropylmalate dehydrogenase, conserved site |
| GO Term | Gene Name |
|---|---|
| GO:0004449 | IPR004434 |
| GO:0006099 | IPR004434 |
| GO:0055114 | IPR004434 |
| DB identifier | Type | Name |
|---|---|---|
| IPR001804 | Family | Isocitrate and isopropylmalate dehydrogenases family |
