| Type: | Domain | Name: | HORMA domain |
| Description: | The HORMA domain (for HOP1, REV7 and MAD2) is an about 180-240 amino acids region containing several conserved motifs. Whereas the MAD2 and the REV7proteins are almost entirely made up of HORMA domains, HOP1 contains a HORMA domain in its N-terminal region and a Zn-finger domain, whose generalarrangement of metal-chelating residues is similar to that of the PHD finger, in the C-terminal region. The HORMA domain is found in proteins showing adirect association with chromatin of all crown group eukaryotes. It has been suggested that the HORMA domain recognises chromatin states that result fromDNA adducts, double-stranded breaks or non-attachment to the spindle and acts as an adaptor that recruits other proteins involved in repair [].Secondary structure prediction suggests that the HORMA domain is globular and could potentially form a complex beta-sheet(s) with associated alpha-helices[].Some proteins known to contain a HORMA domain are listed below:Eukaryotic HOP1, a conserved protein that is involved in meiotic- synaptonemal-complex assembly.Eukaryotic mitotic-arrest-deficient 2 protein (MAD2), a key component of the mitotic-spindle-assembly checkpoint.Eukaryotic REV7, a subunit of the DNA polymerase zeta that is involved in translesion, template-independent DNA synthesis. | Short Name: | HORMA_dom |
