Type: | Domain | Name: | Phospholipase A2 domain |
Description: | This entry represents eukaryotic and prokaryotic phospholipase A2 enzymes (PLA2; ), small lipolytic enzymes that releases fatty acids from the second carbon group of glycerol. These enzymes enable the of fatty acids and lysophospholipid by hydrolysing the 2-ester bond of 1,2-diacyl-3-sn-phosphoglycerides.The phospholipase domain adopts an alpha-helical secondary structure, consisting of five alpha-helices and two helical segments [, ]. In eukaryotes, PLAS plays a pivotal role in the biosynthesis of prostaglandin and other mediators of inflammation. | Short Name: | PLipase_A2_dom |