Protein Domain : IPR011603

Type:  Family Name:  2-oxoglutarate dehydrogenase E1 component
Description:  2-oxoglutarate dehydrogenase is a key enzyme in the TCA cycle, converting 2-oxoglutarate, coenzyme A and NAD(+) to succinyl-CoA, NADH and carbon dioxide []. This activity of this enzyme is tightly regulated and it is a major determinant of the metabolic flux through the TCA cycle. This enzyme is composed of multiple copies of three different subunits: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) which is often shared with similar enzymes such as pyruvate dehydrogenase []. The E2 component forms a large multimeric core which binds the peripheral E1 and E3 subunits. The substrate is transferred between the active sites of the different subunits by a lipoyl moiety, bound to a lysine residue from the E2 polypeptide.The E1 subunit of 2-oxoglutarate dehydrogenase catalyses the decarboxylation of this compound in a thiamine pyrophosphate-dependent manner, transferring the resultant succinyl group onto the liposyl moiety bound to the E2 subunit. The E1 ortholog from Corynebacterium glutamicum(Brevibacterium flavum) is unusual in having an N-terminal extension that resembles the E2 component of 2-oxoglutarate dehydrogenase enzyme. Short Name:  2oxoglutarate_DH_E1
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1 Child Features

DB identifier Type Name
IPR023784 Family 2-oxoglutarate dehydrogenase E1 component, bacterial

2 Contains

DB identifier Type Name
IPR001017 Domain Dehydrogenase, E1 component
IPR005475 Domain Transketolase-like, pyrimidine-binding domain

3 Cross Referencess

Identifier
PTHR23152
PIRSF000157
TIGR00239

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004591 IPR011603
GO:0030976 IPR011603
GO:0006099 IPR011603
GO:0055114 IPR011603

4 Ontology Annotations

GO Term Gene Name
GO:0004591 IPR011603
GO:0030976 IPR011603
GO:0006099 IPR011603
GO:0055114 IPR011603

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
411084 D8RGJ1 PAC:15405591 Selaginella moellendorffii 688  
411081 D8RGI8 PAC:15405587 Selaginella moellendorffii 417  
93779 D8RHR0 PAC:15401330 Selaginella moellendorffii 972  
138697 D8TFY3 PAC:15402257 Selaginella moellendorffii 299  
418242 D8S543 PAC:15405150 Selaginella moellendorffii 737  
418239 D8S540 PAC:15405127 Selaginella moellendorffii 297  
83943 D8R4B2 PAC:15417940 Selaginella moellendorffii 971  
evm.model.supercontig_162.13 PAC:16410234 Carica papaya 1020  
36292.m000013 B9TPF5 PAC:16826905 Ricinus communis 276  
29585.m000605 B9SR44 PAC:16803169 Ricinus communis 244  
29585.m000604 B9SR43 PAC:16803168 Ricinus communis 529  
29585.m000606 B9SR45 PAC:16803170 Ricinus communis 102  
29585.m000607 B9SR46 PAC:16803171 Ricinus communis 1021  
Cucsa.002630.1 PAC:16950932 Cucumis sativus 1021  
Cucsa.002630.2 PAC:16950933 Cucumis sativus 836  
Cucsa.165420.6 A0A0A0KLU6 PAC:16966017 Cucumis sativus 1022  
Cucsa.165420.7 PAC:16966018 Cucumis sativus 896  
Cucsa.165420.3 A0A0A0KLU6 PAC:16966014 Cucumis sativus 1022  
Cucsa.165420.1 A0A0A0KLU6 PAC:16966012 Cucumis sativus 1022  
orange1.1g002323m A0A067DE31 PAC:18117814 Citrus sinensis 936  
orange1.1g002419m A0A067FX15 PAC:18095576 Citrus sinensis 925  
AT5G65750.1 Q9FLH2 PAC:19667385 Arabidopsis thaliana 1025  
AT3G55410.1 F4IWV2 PAC:19662865 Arabidopsis thaliana 1017  
Thhalv10010096m V4L3L8 PAC:20206899 Eutrema salsugineum 996  
Thhalv10010095m V4L3L8 PAC:20206898 Eutrema salsugineum 996  
Thhalv10003576m V4MIS9 PAC:20198570 Eutrema salsugineum 1025  
Ciclev10018656m V4T3X0 PAC:20809567 Citrus clementina 1024  
Lus10029463 PAC:23149368 Linum usitatissimum 1024  
Lus10031476 PAC:23155888 Linum usitatissimum 644  
Lus10015205 PAC:23149500 Linum usitatissimum 1024  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            16321804
            9278141