1 Contains
DB identifier | Type | Name |
---|---|---|
IPR020396 | Conserved_site | NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site |
1 Found In
DB identifier | Type | Name |
---|---|---|
IPR012179 | Family | [NiFe]-hydrogenase-3-type complex Ech, subunit EchD |
Type: | Domain | Name: | NADH:ubiquinone oxidoreductase, 30kDa subunit |
Description: | NADH:ubiquinone oxidoreductase (complex I) () is a respiratory-chain enzyme that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane (NADH + ubiquinone = NAD+ + ubiquinol) []. Complex I is a major source of reactive oxygen species (ROS) that are predominantly formed by electron transfer from FMNH(2). Complex I is found in bacteria, cyanobacteria (as a NADH-plastoquinone oxidoreductase), archaea [], mitochondria, and in the hydrogenosome, a mitochondria-derived organelle. In general, the bacterial complex consists of 14 different subunits, while the mitochondrial complex contains homologues to these subunits in addition to approximately 31 additional proteins []. The 30 kDa subunit from NADH:ubiquinone oxidoreductase is found in both eukaryotes and prokaryotes. In mammals and in Neurospora crassa, it is nuclear-encoded as a precursor form with a transit peptide, while in Paramecium (protein P1), in the Dictyostelium discoideum(Slime mold) it is mitochondrial-encoded and it is chloroplast-encoded in various higher plants. It is also present in bacteria. | Short Name: | NADH_UbQ_OxRdtase_30kDa_su |
DB identifier | Type | Name |
---|---|---|
IPR020396 | Conserved_site | NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site |
DB identifier | Type | Name |
---|---|---|
IPR012179 | Family | [NiFe]-hydrogenase-3-type complex Ech, subunit EchD |