Protein Domain : IPR005122

Type:  Domain Name:  Uracil-DNA glycosylase-like
Description:  This entry represents various uracil-DNA glycosylases and related DNA glycosylases (), such as uracil-DNA glycosylase [], thermophilic uracil-DNA glycosylase [], G:T/U mismatch-specific DNA glycosylase (Mug) [], and single-strand selective monofunctional uracil-DNA glycosylase (SMUG1) []. These proteins have a 3-layer alpha/beta/alpha structure.Uracil-DNA glycosylases are DNA repair enzymes that excise uracil residues from DNA by cleaving the N-glycosylic bond, initiating the base excision repair pathway. Uracil in DNA can arise either through the deamination of cytosine to form mutagenic U:G mispairs, or through the incorporation of dUMP by DNA polymerase to form U:A pairs []. These aberrant uracil residues are genotoxic []. The sequence of uracil-DNA glycosylase is extremely well conserved [] in bacteria and eukaryotes as well as in herpes viruses. More distantly related uracil-DNA glycosylases are also found in poxviruses []. Short Name:  Uracil-DNA_glycosylase-like
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1 Child Features

DB identifier Type Name
IPR005273 Domain Uracil-DNA glycosylase, family 4 domain

1 Contains

DB identifier Type Name
IPR018085 Active_site Uracil-DNA glycosylase, active site

4 Cross Referencess

Identifier
PF03167
SM00986
G3DSA:3.40.470.10
SSF52141

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

818 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
46714 D8TEC5 PAC:15418688 Selaginella moellendorffii 250  
66695 D8QVE1 PAC:15410199 Selaginella moellendorffii 280  
78447 D8QVE0 PAC:15421426 Selaginella moellendorffii 275  
evm.model.supercontig_0.166 PAC:16403876 Carica papaya 265  
evm.model.supercontig_37.92 PAC:16418769 Carica papaya 1124  
29725.m000234 B9S678 PAC:16806599 Ricinus communis 332  
30147.m013981 B9RB56 PAC:16819996 Ricinus communis 983  
33675.m000032 B9TDK4 PAC:16825953 Ricinus communis 198  
59263.m000015 B9TP77 PAC:16829240 Ricinus communis 166  
27851.m000041 B9TBL8 PAC:16799338 Ricinus communis 214  
28702.m000025 B9TET4 PAC:16801557 Ricinus communis 303  
Cucsa.373300.1 A0A0A0KMG3 PAC:16981842 Cucumis sativus 318  
Cucsa.177560.1 A0A0A0LD45 PAC:16967034 Cucumis sativus 451  
Cucsa.177560.2 A0A0A0LD45 PAC:16967035 Cucumis sativus 451  
Cucsa.177560.3 A0A0A0LD45 PAC:16967036 Cucumis sativus 451  
orange1.1g043454m A0A067D4R4 PAC:18094624 Citrus sinensis 251  
orange1.1g038649m A0A067ERK9 PAC:18139787 Citrus sinensis 130  
orange1.1g047176m A0A067ERS5 PAC:18139782 Citrus sinensis 222  
AT3G18630.1 Q9LIH6 PAC:19662454 Arabidopsis thaliana 330  
Thhalv10021116m V4NNJ0 PAC:20183654 Eutrema salsugineum 330  
Ciclev10006661m V4S0V4 PAC:20790453 Citrus clementina 225  
Lus10012898 PAC:23162999 Linum usitatissimum 347  
Lus10030553 PAC:23140569 Linum usitatissimum 346  
Potri.008G085900.1 B9HI65 PAC:27039476 Populus trichocarpa 128  
Potri.008G085900.2 A0A2K1ZE22 PAC:27039477 Populus trichocarpa 122  
Potri.010G169600.2 B9HY10 PAC:26982832 Populus trichocarpa 311  
Potri.010G169600.1 PAC:26982831 Populus trichocarpa 341  
Gorai.008G031500.12 A0A0D2STZ1 PAC:26815546 Gossypium raimondii 252  
Gorai.008G031500.13 A0A0D2STZ1 PAC:26815547 Gossypium raimondii 252  
Gorai.008G031500.4 A0A0D2STZ6 PAC:26815538 Gossypium raimondii 339  

8 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7697717
            2555154
            8389453
            9489705
            10339434
            2820976
            16860315
            17116429