| Type: | Family | Name: | Histidinol dehydrogenase |
| Description: | Histidinol dehydrogenase (HDH) catalyzes the terminal step in the biosynthesis of histidine in bacteria, fungi, and plants, the four-electron oxidation of L-histidinol to histidine.In 4-electron dehydrogenases, a single active site catalyses 2 separate oxidation steps: oxidation of the substrate alcohol to an intermediate aldehyde; and oxidation of the aldehyde to the product acid, in this case His []. The reaction proceeds via a tightly- or covalently-bound inter-mediate, and requires the presence of 2 NAD molecules []. By contrast with most dehydrogenases, the substrate is bound before the NAD coenzyme []. A Cys residue has been implicated in the catalytic mechanism of the second oxidative step [].In bacteria HDH is a single chain polypeptide; in fungi it is the C-terminal domain of a multifunctional enzyme which catalyzes three different steps of histidine biosynthesis; and in plants it is expressed as nuclear encoded protein precursor which is exported to the chloroplast []. | Short Name: | Hstdl_DH |
| DB identifier | Type | Name |
|---|---|---|
| IPR001692 | Conserved_site | Histidinol dehydrogenase, conserved site |
| GO Term | Gene Name |
|---|---|
| GO:0004399 | IPR012131 |
| GO:0008270 | IPR012131 |
| GO:0051287 | IPR012131 |
| GO:0000105 | IPR012131 |
| GO:0055114 | IPR012131 |
| GO Term | Gene Name |
|---|---|
| GO:0004399 | IPR012131 |
| GO:0008270 | IPR012131 |
| GO:0051287 | IPR012131 |
| GO:0000105 | IPR012131 |
| GO:0055114 | IPR012131 |
