Protein Domain : IPR020810

Type:  Domain Name:  Enolase, C-terminal
Description:  Enolase (2-phospho-D-glycerate hydrolase) is an essential glycolytic enzyme that catalyses the interconversion of 2-phosphoglycerate and phosphoenolpyruvate [, ]. In vertebrates, there are 3 different, tissue-specific isoenzymes, designated alpha, beta and gamma. Alpha is present in most tissues, beta is localised in muscle tissue, and gamma is found only in nervous tissue. The functional enzyme exists as a dimer of any 2 isoforms. In immature organs and in adult liver, it is usually an alpha homodimer, in adult skeletal muscle, a beta homodimer, and in adult neurons, a gamma homodimer. In developing muscle, it is usually an alpha/beta heterodimer, and in the developing nervous system, an alpha/gamma heterodimer []. The tissue specific forms display minor kinetic differences. Tau-crystallin, one of the major lens proteins in some fish, reptiles and birds, has been shown [] to be evolutionary related to enolase.Neuron-specific enolase is released in a variety of neurological diseases, such as multiple sclerosis and after seizures or acute stroke. Several tumour cells have also been found positive for neuron-specific enolase. Beta-enolase deficiency is associated with glycogenosis type XIII defect. Short Name:  Enolase_C
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0 Child Features

1 Contains

DB identifier Type Name
IPR020809 Conserved_site Enolase, conserved site

1 Cross References

Identifier
PF00113

1 Found In

DB identifier Type Name
IPR000941 Family Enolase

4 GO Annotations

GO Term Gene Name
GO:0000287 IPR020810
GO:0004634 IPR020810
GO:0006096 IPR020810
GO:0000015 IPR020810

4 Ontology Annotations

GO Term Gene Name
GO:0000287 IPR020810
GO:0004634 IPR020810
GO:0006096 IPR020810
GO:0000015 IPR020810

1 Parent Features

DB identifier Type Name
IPR029065 Domain Enolase C-terminal domain-like

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
96269 D8RLY3 PAC:15406265 Selaginella moellendorffii 494  
165356 D8QU68 PAC:15412720 Selaginella moellendorffii 479  
78644 D8QV15 PAC:15422960 Selaginella moellendorffii 480  
167539 D8R303 PAC:15420040 Selaginella moellendorffii 446  
evm.model.supercontig_112.83 PAC:16405988 Carica papaya 123  
evm.model.supercontig_13.89 PAC:16407899 Carica papaya 483  
evm.model.supercontig_3.274 PAC:16416562 Carica papaya 461  
evm.model.supercontig_5.86 PAC:16421539 Carica papaya 385  
29751.m001807 B9S376 PAC:16807815 Ricinus communis 469  
30147.m014180 B9R9N6 PAC:16820192 Ricinus communis 445  
30174.m009039 B9RE72 PAC:16822680 Ricinus communis 490  
29092.m000447 B9SRG1 PAC:16802268 Ricinus communis 445  
Cucsa.083090.10 A0A0A0KIK3 PAC:16956363 Cucumis sativus 444  
Cucsa.083090.1 PAC:16956362 Cucumis sativus 453  
Cucsa.146810.1 A0A0A0M0P5 PAC:16963969 Cucumis sativus 483  
Cucsa.198370.1 A0A0A0LPK6 PAC:16968583 Cucumis sativus 492  
orange1.1g040341m A0A067DHH5 PAC:18103068 Citrus sinensis 251  
orange1.1g013317m A0A067FQD2 PAC:18127895 Citrus sinensis 445  
orange1.1g011677m PAC:18111194 Citrus sinensis 479  
orange1.1g043137m A0A067F0Y6 PAC:18101066 Citrus sinensis 445  
orange1.1g012041m A0A067FHG9 PAC:18133646 Citrus sinensis 472  
orange1.1g016156m A0A067FQX5 PAC:18133647 Citrus sinensis 394  
AT1G74030.1 Q9C9C4 PAC:19656394 Arabidopsis thaliana 477  
AT2G36530.1 P25696 PAC:19638768 Arabidopsis thaliana 444  
AT2G29560.1 Q9ZW34 PAC:19642848 Arabidopsis thaliana 475  
Thhalv10016594m V4NX60 PAC:20180224 Eutrema salsugineum 476  
Thhalv10010379m V4LN70 PAC:20207525 Eutrema salsugineum 444  
Thhalv10010378m V4LZ65 PAC:20206910 Eutrema salsugineum 444  
Thhalv10018478m V4KD95 PAC:20191373 Eutrema salsugineum 479  
Ciclev10012056m V4UV38 PAC:20799174 Citrus clementina 356  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3390159
            1840492
            1859865
            3589669