Protein Domain : IPR026825

Type:  Family Name:  Vacuole morphology and inheritance protein 14
Description:  Vac14 is a component of the PI(3,5)P2 regulatory complex, which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) []. This complex is composed of Atg18, Fig4, Fab1, Vac14 and Vac7 in yeast. In mammals it consists of PIKfyve, FIG4 and VAC14. Fab1/PIKfyve (Fab1 in yeast and PIKfyve in mammals) is a kinase that converts PI(3)P into PI(3,5)P2 by phosphorylation at the 5-position; conversely Fig4 dephosphorylates PI(3,5)P2 back to PI(3)P. Vac14 is a scaffolding adaptor protein whose multimerisation is a prerequisite step for PI(3,5)P2 complex assembly and function []. Short Name:  Vac14
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR16023

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0043550 IPR026825
GO:0070772 IPR026825

2 Ontology Annotations

GO Term Gene Name
GO:0043550 IPR026825
GO:0070772 IPR026825

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
172660 D8RMD2 PAC:15413499 Selaginella moellendorffii 723  
evm.model.supercontig_2.195 PAC:16412558 Carica papaya 543  
29673.m000944 B9SJ28 PAC:16805336 Ricinus communis 728  
orange1.1g005727m A0A067FC47 PAC:18095076 Citrus sinensis 680  
orange1.1g010666m A0A067F3T6 PAC:18095080 Citrus sinensis 504  
orange1.1g009182m A0A067FBD1 PAC:18095079 Citrus sinensis 541  
orange1.1g005891m A0A067F054 PAC:18095077 Citrus sinensis 671  
orange1.1g005975m A0A067F098 PAC:18095078 Citrus sinensis 666  
AT2G01690.1 Q9ZU97 PAC:19639359 Arabidopsis thaliana 743  
AT2G01690.2 F4IPA6 PAC:19639358 Arabidopsis thaliana 744  
Thhalv10003708m V4KT05 PAC:20200025 Eutrema salsugineum 737  
Ciclev10014409m V4UGH4 PAC:20817257 Citrus clementina 725  
Lus10001587 PAC:23169283 Linum usitatissimum 732  
Lus10034578 PAC:23162703 Linum usitatissimum 729  
Lus10021813 PAC:23159313 Linum usitatissimum 997  
Lus10003679 PAC:23179491 Linum usitatissimum 708  
Lus10003702 PAC:23179468 Linum usitatissimum 756  
Potri.010G106700.1 U5G1J3 PAC:26978676 Populus trichocarpa 725  
Potri.010G106700.2 PAC:26978677 Populus trichocarpa 724  
Potri.008G134600.2 PAC:27037028 Populus trichocarpa 723  
Potri.008G134600.5 A0A2K1ZGN0 PAC:27037031 Populus trichocarpa 506  
Potri.008G134600.3 PAC:27037029 Populus trichocarpa 592  
Potri.008G134600.4 A0A2K1ZGP7 PAC:27037030 Populus trichocarpa 546  
Potri.008G134600.1 A0A2K1ZGN5 PAC:27037027 Populus trichocarpa 725  
Gorai.002G172300.9 A0A0D2MC91 PAC:26796397 Gossypium raimondii 408  
Gorai.002G172300.6 A0A0D2Q7X1 PAC:26796394 Gossypium raimondii 573  
Gorai.002G172300.7 A0A0D2Q7X9 PAC:26796395 Gossypium raimondii 539  
Gorai.002G172300.8 A0A0D2NPA5 PAC:26796396 Gossypium raimondii 478  
Gorai.002G172300.2 A0A0D2NPA7 PAC:26796391 Gossypium raimondii 720  
Gorai.002G172300.4 A0A0D2R7U6 PAC:26796392 Gossypium raimondii 631  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            19037259
            23389034