| Type: | Family | Name: | Uroporphyrinogen decarboxylase HemE |
| Description: | This entry represents uroporphyrinogen decarboxylase (HemE), which catalyzes the fifth step in the haem biosynthetic pathway, converting uroporphyrinogen III to coproporphyrinogen III by decarboxylating the four acetate side chains of thesubstrate []. This step takes the pathway toward protoporphyrin IX, a common precursor of both haem and chlorophyll, rather than toward precorrin 2 and its products.This activity is essential in all organisms, and subnormal activity of URO-D leads to the most common form of porphyria in humans, porphyria cutanea tarda (PCT). | Short Name: | Uroporphyrinogen_deCO2ase_HemE |
