3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0006281 | IPR030559 |
| GO:0019985 | IPR030559 |
| GO:0016035 | IPR030559 |
| Type: | Family | Name: | DNA polymerase zeta catalytic subunit |
| Description: | DNA polymerase zeta (Pol zeta) belongs to the B-family of polymerases. It is a nonessential DNA polymerase responsible for the majority of damage-induced mutagenesis in eukaryotes []. It is involved in double-strand breaks DNA repair [] and has a major role in translesion DNA synthesis (TLS) , an alternative DNA damage tolerance mechanism that allows the DNA replication machinery to replicate past DNA lesions [, ]. Pol zeta lacks proofreading activity and its discrimination against insertion of incorrect bases is lower than that of other B-family polymerases []. Discrimination against ribonucleotide incorporation is only slightly lower than in the case of the replicative DNA polymerases [].Originally discovered in budding yeast, genes encoding this enzyme have been found in all fully sequenced eukaryotic genomes []. Its role in translesion replication is probably the most widespread []. | Short Name: | PolZ_Rev3 |
| GO Term | Gene Name |
|---|---|
| GO:0006281 | IPR030559 |
| GO:0019985 | IPR030559 |
| GO:0016035 | IPR030559 |
