Protein Domain : IPR008728

Type:  Family Name:  Elongator complex protein 4
Description:  Elongator is a 6 subunit protein complex highly conserved in eukaryotes. The human Elongator six-subunit complex, known as holo-Elongator, has histone acetyltransferase activity directed against histone H3 and H4 [, ]. It consists of two subcomplexes, a core subcomplex (ELP1-3), and an accessory subcomplex (ELP4-6) []. Human Elongator facilitates transcription by RNA polymerase II in a chromatin- and acetyl-CoA-dependent manner []. In yeast, the primary and probably only role of this complex is in formation of the 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) side chains on uridines at wobble position in tRNA [, ].This entry represents the ELP4 subunit. Mammalian ELP4 gene is implicated in rolandic epilepsy []. Short Name:  Elongator_complex_protein_4
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PTHR12896
PF05625

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0033588 IPR008728

1 Ontology Annotations

GO Term Gene Name
GO:0033588 IPR008728

0 Parent Features

527 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
413865 D8RQG8 PAC:15417575 Selaginella moellendorffii 242  
evm.model.supercontig_19.179 PAC:16411915 Carica papaya 312  
28833.m000153 B9T5X5 PAC:16801767 Ricinus communis 363  
Cucsa.103850.1 A0A0A0KLQ1 PAC:16959101 Cucumis sativus 362  
Cucsa.103850.2 A0A0A0KLQ1 PAC:16959102 Cucumis sativus 362  
orange1.1g013117m A0A067DUE2 PAC:18130627 Citrus sinensis 449  
AT3G11220.2 PAC:19659798 Arabidopsis thaliana 373  
AT3G11220.1 Q9C778 PAC:19659799 Arabidopsis thaliana 355  
Thhalv10021017m V4M260 PAC:20181889 Eutrema salsugineum 356  
Ciclev10008715m V4TWJ5 PAC:20793568 Citrus clementina 366  
Ciclev10008278m V4WEH9 PAC:20795348 Citrus clementina 449  
Lus10032284 PAC:23168675 Linum usitatissimum 474  
Lus10024652 PAC:23161604 Linum usitatissimum 317  
Potri.008G067800.1 B9HHP0 PAC:27035908 Populus trichocarpa 88  
Potri.010G189500.2 B9HSP5 PAC:26980329 Populus trichocarpa 363  
Potri.010G189500.1 B9HSP5 PAC:26980330 Populus trichocarpa 363  
Potri.010G189500.3 PAC:26980331 Populus trichocarpa 316  
Gorai.008G084700.4 A0A0D2RBY2 PAC:26816898 Gossypium raimondii 217  
Gorai.008G084700.3 A0A0D2SX75 PAC:26816896 Gossypium raimondii 307  
Gorai.008G084700.5 A0A0D2PR39 PAC:26816897 Gossypium raimondii 303  
Gorai.008G084700.2 A0A0D2T2L5 PAC:26816895 Gossypium raimondii 360  
Gorai.008G084700.1 A0A0D2T2L5 PAC:26816894 Gossypium raimondii 360  
40910 I0Z1M5 PAC:27387412 Coccomyxa subellipsoidea C-169 316  
214193 C1N6W2 PAC:27348689 Micromonas pusilla CCMP1545 503  
63634 C1EGG4 PAC:27402515 Micromonas sp RCC299 514  
94067 A4SAZ1 PAC:27420332 Ostreococcus lucimarinus 429  
Thecc1EG042519t2 A0A061FL38 PAC:27443366 Theobroma cacao 363  
Thecc1EG042519t1 A0A061FKF3 PAC:27443365 Theobroma cacao 387  
Thecc1EG042519t3 A0A061FM97 PAC:27443367 Theobroma cacao 306  
Thecc1EG041355t1 A0A061GVD8 PAC:27430135 Theobroma cacao 333  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11904415
            15769872
            25607684
            11714725
            11818576
            19172991
            22556426