Protein Domain : IPR001453

Type:  Domain Name:  MoaB/Mog domain
Description:  MoaB/Mog domain, also known as Cnx1G domain, is found in the bacterial molybdenum cofactor (Moco) biosynthesis protein MoaB/Mog and N-terminal of the eukaryotic MoCF biosynthesis proteins, such as the Drosophila protein cinnamon, the Arabidopsis protein cnx1 and the mammal protein gephyrin []. These proteins are involved in the final steps of Moco synthesis. In E. coli two proteins, MogA and MoeA are essential for Mo insertion into molybdopterin, while in plants and animals one fusion protein with two domains (G and E domains) fulfils this function. The G domain of Cnx1 and gephyrin shares similarity with MoaB/Mog, while their E domain displays similarities to the sulfurtransferase rhodanese (homologous to E. coli MoeA/chlE) []. Structurally, MogA is folded into a compact molecule with alpha/beta/alpha architecture and forms a trimer []. The Cnx1G domain has been shown to bind molybdopterin []. This domain is also found in N-terminal of the FAD synthases belonging to the COG1058 family that catalyses the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme []. The COG1058 family member CinA from Thermus thermophilus is shown to have both nicotinamide mononucleotide deamidase and ADP-ribose pyrophosphatase activities []. Short Name:  MoaB/Mog_dom
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0 Child Features

1 Contains

DB identifier Type Name
IPR008284 Conserved_site Molybdenum cofactor biosynthesis, conserved site

5 Cross Referencess

Identifier
PF00994
SM00852
TIGR00177
G3DSA:3.40.980.10
SSF53218

7 Found Ins

DB identifier Type Name
IPR013484 Family Molybdenum cofactor biosynthesis protein B, proteobacteria
IPR008135 Family Competence-induced protein CinA
IPR012182 Family Bifunctional molybdenum cofactor biosynthesis MobB/MoeA
IPR012183 Family FAD synthetase with the MoaB/Mog domain
IPR012184 Family Bifunctional molybdopterin binding protein /nucleotidyl transferase, putative
IPR012247 Family Bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA
IPR012245 Family Molybdenum cofactor biosynthesis protein MoaB

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
54760 D8RPX3 PAC:15420134 Selaginella moellendorffii 414  
149120 D8RR45 PAC:15408323 Selaginella moellendorffii 641  
99767 D8RRC7 PAC:15418943 Selaginella moellendorffii 107  
123348 D8SRV1 PAC:15422648 Selaginella moellendorffii 70  
evm.model.supercontig_1.264 PAC:16404193 Carica papaya 161  
evm.model.supercontig_106.53 PAC:16405219 Carica papaya 180  
evm.model.supercontig_34.224 PAC:16417965 Carica papaya 599  
29854.m001110 B9RQ35 PAC:16811622 Ricinus communis 668  
30078.m002280 B9S0G3 PAC:16817391 Ricinus communis 512  
30174.m008802 B9RD46 PAC:16822447 Ricinus communis 166  
47040.m000021 B9TM03 PAC:16827953 Ricinus communis 136  
28953.m000081 B9T8Z1 PAC:16802021 Ricinus communis 257  
Cucsa.040120.1 A0A0A0KTG2 PAC:16952757 Cucumis sativus 179  
Cucsa.142470.1 PAC:16963647 Cucumis sativus 661  
Cucsa.239750.1 PAC:16970808 Cucumis sativus 170  
Cucsa.306680.1 A0A0A0LDK7 PAC:16976096 Cucumis sativus 512  
orange1.1g017354m PAC:18125994 Citrus sinensis 373  
orange1.1g017327m PAC:18125995 Citrus sinensis 373  
orange1.1g011289m A0A067E8U9 PAC:18110408 Citrus sinensis 489  
orange1.1g005900m PAC:18110406 Citrus sinensis 671  
orange1.1g011276m A0A067E8U9 PAC:18110409 Citrus sinensis 489  
orange1.1g005887m PAC:18110407 Citrus sinensis 671  
AT5G03430.1 Q9LZE4 PAC:19667478 Arabidopsis thaliana 497  
AT5G20990.1 Q39054 PAC:19668081 Arabidopsis thaliana 670  
AT1G13390.1 Q9FX58 PAC:19657176 Arabidopsis thaliana 176  
AT1G13390.2 Q9FX58 PAC:19657177 Arabidopsis thaliana 176  
Thhalv10012894m V4LEK6 PAC:20203334 Eutrema salsugineum 669  
Thhalv10013303m V4LCX3 PAC:20205854 Eutrema salsugineum 507  
Thhalv10013301m V4LCX3 PAC:20205855 Eutrema salsugineum 507  
Thhalv10013337m V4KQP2 PAC:20205856 Eutrema salsugineum 499  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10636880
            12590921
            15073332
            23776507
            19675644
            25313401