Protein Domain : IPR008384

Type:  Family Name:  Actin-related protein 2/3 complex subunit 4
Description:  Arp2/3 binds to pre-existing actin filaments and nucleates new daughter filaments, and thus becomes incorporated into the dynamic actin network at the leading edge of motile cells and other actin-based protrusive structures []. In order to nucleate filaments, Arp2/3 must bind to a member of the N-WASp/SCAR family protein []. Arp2 and Arp3 are thought to be brought together after activation, forming an actin-like nucleus for actin monomers to bind and create a new actin filament. In the absence of an activating protein, Arp2/3 shows very little nucleation activity. Recent research has focused on the binding and hydrolysis of ATP by Arp2 and Arp3 [], and crystal structures of the Arp2/3 complex have been solved [].The human complex consists of Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. This family represents the ARPC4/p20-ARC subunit. Short Name:  ARPC4
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0 Child Features

0 Contains

3 Cross Referencess

Identifier
PTHR22629
PF05856
PIRSF039100

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0030041 IPR008384
GO:0034314 IPR008384
GO:0005885 IPR008384
GO:0015629 IPR008384

4 Ontology Annotations

GO Term Gene Name
GO:0030041 IPR008384
GO:0034314 IPR008384
GO:0005885 IPR008384
GO:0015629 IPR008384

0 Parent Features

451 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
98964 D8RQG4 PAC:15417514 Selaginella moellendorffii 168  
evm.TU.contig_27575.2 PAC:16429515 Carica papaya 92  
29904.m002907 B9RWE0 PAC:16812552 Ricinus communis 169  
Cucsa.244560.2 PAC:16971318 Cucumis sativus 169  
Cucsa.244560.3 A0A0A0L985 PAC:16971319 Cucumis sativus 152  
Cucsa.266050.1 A0A0A0LHM5 PAC:16973341 Cucumis sativus 169  
orange1.1g028136m PAC:18100481 Citrus sinensis 213  
AT4G14147.1 F4JUL9 PAC:19646374 Arabidopsis thaliana 169  
AT4G14147.2 F4JUL8 PAC:19646373 Arabidopsis thaliana 176  
Thhalv10026384m V4LZX6 PAC:20194237 Eutrema salsugineum 174  
Thhalv10026411m V4MI11 PAC:20194238 Eutrema salsugineum 169  
Ciclev10006063m V4RJH2 PAC:20789619 Citrus clementina 169  
Lus10038118 PAC:23163708 Linum usitatissimum 908  
Lus10027499 PAC:23144572 Linum usitatissimum 666  
Potri.017G057400.2 A0A2K1X3S2 PAC:26985288 Populus trichocarpa 139  
Potri.017G057400.6 PAC:26985286 Populus trichocarpa 152  
Potri.017G057400.3 B9N0S0 PAC:26985284 Populus trichocarpa 169  
Potri.017G057400.4 PAC:26985289 Populus trichocarpa 132  
Potri.017G057400.7 PAC:26985287 Populus trichocarpa 144  
Potri.017G057400.8 PAC:26985290 Populus trichocarpa 117  
Potri.017G057400.1 PAC:26985283 Populus trichocarpa 175  
Potri.017G057400.5 PAC:26985285 Populus trichocarpa 163  
Gorai.005G030800.2 A0A0D2S9R5 PAC:26806138 Gossypium raimondii 168  
Gorai.005G030800.1 A0A0D2S9R5 PAC:26806139 Gossypium raimondii 168  
86040 A4RQN4 PAC:27417515 Ostreococcus lucimarinus 171  
Thecc1EG020286t1 A0A061EK66 PAC:27455076 Theobroma cacao 169  
Thecc1EG020286t2 A0A061ELJ7 PAC:27455075 Theobroma cacao 170  
Migut.G00716.1.p PAC:28942749 Mimulus guttatus 169  
Araha.1421s0001.1.p PAC:28847066 Arabidopsis halleri 169  
Cagra.6617s0007.1.p PAC:28917730 Capsella grandiflora 169  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9889097
            15505213
            9600938
            11752435